FB2024_03 , released June 25, 2024
Allele: Dmel\Rbfox1KK109100
Open Close
General Information
Symbol
Dmel\Rbfox1KK109100
Species
D. melanogaster
Name
FlyBase ID
FBal0259771
Feature type
allele
Associated gene
Dmel\Rbfox1
Associated Insertion(s)
Carried in Construct
P{KK109100}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK109100}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK109100
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intellectual disability
      CEA
      (Guven-Ozkan et al., 2016)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  intellectual disability
      is ameliorated by mir-980sponge.V2.UAS.mCherry
      (Guven-Ozkan et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of Rbfox1KK109100 RNAi (together with UAS-Dcr2 to enhance RNAi efficiency) under the control of Scer\GAL4GMR13F02 decreases 3 hr memory in an aversive olfactory memory assay in adults compared to controls without altering odor or shock avoidance.

      (Guven-Ozkan et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased 3 hr memory in an aversive olfactory assay characteristic for adult expressing mir-980sponge.V2.Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4elav-C155 is fully suppressed by co-expression of Rbfox1KK109100 RNAi. The memory index measured in flies expressing both transgenes is comparable to that observed in flies expressing Rbfox1KK109100 alone and below the control levels, indicating that mir-980 is epistatic to Rbfox1 in memory control.

      (Guven-Ozkan et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      A2bp1KK109100
      Rbfox1KK109100
      Name Synonyms
      Secondary FlyBase IDs
        References (5)