FB2024_03 , released June 25, 2024
Allele: Scer\GAL4Ir25a.PA
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General Information
Symbol
Scer\GAL4Ir25a.PA
Species
S. cerevisiae
Name
Ionotropic receptor 25a promoter construct of Abuin
FlyBase ID
FBal0249373
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{Ir25a-GAL4.A}
Also Known As
IR25a-gal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Abuin et al., 2011)
Progenitor genotype
Carried in construct
P{Ir25a-GAL4.A}
Cytology
Description

Ir25a promoter sequences regulate expression of a GAL4 driver.

(Abuin et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Ir25a
Ir25a_651bp
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      terminal organ ganglion
      (Omelchenko et al., 2022)
      ventral organ ganglion
      (Omelchenko et al., 2022)
      dorsal organ ganglion
      (Omelchenko et al., 2022)
      dorsopharyngeal organ
      (Omelchenko et al., 2022)
      hypopharyngeal organ
      (Omelchenko et al., 2022)
      epiphysis
      (Omelchenko et al., 2022)
      hypophysis
      (Omelchenko et al., 2022)
      adult stage
      neuron of antennal coeloconic sensillum ac1
      (Silbering et al., 2011)
      neuron of antennal coeloconic sensillum ac2
      (Silbering et al., 2011)
      neuron of antennal coeloconic sensillum ac3
      (Silbering et al., 2011)
      neuron of antennal coeloconic sensillum ac4
      (Silbering et al., 2011)
      neuron of sensillum of sacculus chamber I
      (Silbering et al., 2011)
      neuron of sensillum of sacculus chamber II
      (Silbering et al., 2011)
      neuron of aristal sensillum
      (Enjin et al., 2016, Silbering et al., 2011)
      adult antennal lobe glomerulus | subset
      (Silbering et al., 2011)
      gustatory receptor neuron of the labellum | subset
      (Lee et al., 2018)
      gustatory receptor neuron of leg
      (Lee et al., 2018)
      calcium-sensing neuron of labellar S-type taste bristle
      (Lee et al., 2018)
      metathoracic leg taste bristle chemosensory neuron | subset
      (Sánchez-Alcañiz et al., 2018)
      labral sense organ neuron
      (Sánchez-Alcañiz et al., 2018)
      gustatory receptor neuron of labellar taste bristle
      (Sánchez-Alcañiz et al., 2018)
      adult antennal olfactory receptor neuron | subset
      (Sánchez-Alcañiz et al., 2018)
      adult hygrosensory neuron Ir40a VP4
      (Sun et al., 2018)
      chamber II of sacculus
      (Sun et al., 2018)
      prothoracic leg taste bristle chemosensory neuron
      (Ahn et al., 2017)
      bitter-sensing neuron of the leg
      (Ahn et al., 2017)
      gustatory receptor neuron of the labellum
      (Ahn et al., 2017)
      mechanosensory neuron of femoral chordotonal organ | subset
      (Chen et al., 2015)
      Johnston organ neuron | subset
      (Chen et al., 2015)
      non-aristal sensory neuron VP3
      (Alpert et al., 2020)
      adult thermosensory neuron
      (Enjin et al., 2016)
      adult hygrosensory neuron Ir40a
      (Enjin et al., 2016)
      Additional Information
      Statement
      Reference

      ScerGAL4Ir25a.PA drives expression in many larval anterior chemosensory organs, including the terminal organ ganglion (TOG), ventral organ ganglion (VOG), dorsal organ ganglion (DOG), dorsopharyngeal organ (DPO), hypopharyngeal organ (posterior pharyngeal sensilla, PPS), epiphysis (dorsal pharyngeal sensilla, DPS), and hypophysis (ventral pharyngeal sensilla, VPS).

      (Omelchenko et al., 2022)

      ScerGAL4Ir25a.PA drives expression in the gustatory receptor neurons of the labellum that overlaps extensively with that of Ir25a, and with gustatory receptor neurons in the leg that are positive for ScerGAL4Ir76b.1.5.

      (Lee et al., 2018)

      This GAL4 line drives expression in hygrosensitive neurons in the second chamber of the sacculus.

      (Sun et al., 2018)

      Expression is observed in multiple gustatory receptor neurons per sensillum. In the tarsal sensilla, expression largely overlaps and includes sweet and bitter gustatory receptor neurons. Expression also occurs in multiple neurons per sensillum in the labial palps.

      (Ahn et al., 2017)

      Drives expression in a subset of bitter-sensing, hygrosensory, and cold-sensing thermosensory neurons in the labellum, legs, arista, sacculus, antenna, labrum, and larval head sensory organs

      (FlyBase Curators, 2017)

      ScerGAL4Ir25a.PA drives expression in thermosensory neurons of the arista, and in hygrosensory neurons in sacculus chambers I, II and III.

      (Enjin et al., 2016)

      ScerGAL4Ir25a.PA drives expression in a subset of neurons of the femoral chordotonal organs and Johnston organ. These neurons coexpress NcraQFnompC.PP.

      (Chen et al., 2015)

      ScerGAL4Ir25a.PA is expressed in the neurons that innervate the antennal coeloconic sensillum ac1-a4, basiconic and blunt-tipped sensillum of sacculus, aristal sensillum and in a subset of antennal lobe glomeruli.

      (Silbering et al., 2011)
       
      Marker for
      Reflects expression of
      Ir25a
      (Alpert et al., 2020, Lee et al., 2018, Sun et al., 2018, Ahn et al., 2017, Enjin et al., 2016, Chen et al., 2015, Silbering et al., 2011)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4Ir25a.PA
      Name Synonyms
      Ionotropic receptor 25a promoter construct of Abuin
      Secondary FlyBase IDs
        References (25)