FB2024_03 , released June 25, 2024
Allele: Dmel\Ir25aUAS.cAa
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General Information
Symbol
Dmel\Ir25aUAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Abuin
FlyBase ID
FBal0249355
Feature type
allele
Associated gene
Dmel\Ir25a
Associated Insertion(s)
Carried in Construct
M{UAS-Ir25a.A}
Also Known As
UAS-IR25a
Key Links
Transgenic product class
wild_type
(Abuin et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Abuin et al., 2011)
Mutagen
in vitro construct
(Abuin et al., 2011)
Progenitor genotype
Carried in construct
M{UAS-Ir25a.A}
Cytology
Description

UAS regulatory sequences drive expression of Ir25a.

(Abuin et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ir25a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ir25aUAS.cAa under the control of Scer\GAL4Pdf.PU results in a temperature-dependent increase in action potential firing frequency in large lateral ventral (l-LNv) cells, compared to controls.

      (Chen et al., 2015)

      Neurons expressing Ir25aScer\UAS.cAa driven by Scer\GAL4Or22a.7.717 do not respond to phenylethyl amine above basal solvent-evoked activity.

      (Abuin et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Neurons co-expressing Ir25aScer\UAS.cAa and Ir76aScer\UAS.cBa driven by Scer\GAL4Or22a.7.717 do not respond to phenylethyl amine above basal solvent-evoked activity.

      Neurons co-expressing Ir25aScer\UAS.cAa and Ir76bScer\UAS.cAa driven by Scer\GAL4Or22a.7.717 do not respond to phenylethyl amine above basal solvent-evoked activity.

      Neurons co-expressing Ir25aScer\UAS.cAa with Ir76aScer\UAS.cBa and Ir76bScer\UAS.cAa driven by Scer\GAL4Or22a.7.717 show a robust response to phenylethyl amine.

      (Abuin et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Gr64f.9.7/Ir25aUAS.cAa rescues Ir25a1

      (Ahn et al., 2017)
      Partially rescues

      Scer\GAL4Ir25a.PA/Ir25aUAS.cAa partially rescues Ir25a1

      (Ahn et al., 2017)

      Scer\GAL4Ir76b.1.5/Ir25aUAS.cAa partially rescues Ir25a2

      (Chen and Amrein, 2017)

      Scer\GAL4Ir25a.PA/Ir25aUAS.cAa partially rescues Ir25a2

      (Abuin et al., 2011)
      Fails to rescue

      Scer\GAL4Ir25a.PA/Ir25aUAS.cAa fails to rescue Ir25a2

      (Chen and Amrein, 2017)
      Comments

      Expression of Ir25aScer\UAS.cAa driven by Scer\GAL4Ir25a.PA partially rescues the odor-evoked electrophysiological response phenotypes in Ir25a2 mutant coeloconic sensilla.

      (Abuin et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ir25aScer\UAS.cAa
      Ir25aUAS.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Abuin
      Secondary FlyBase IDs
        References (9)