FB2024_03 , released June 25, 2024
Allele: Dmel\Ir25a1
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General Information
Symbol
Dmel\Ir25a1
Species
D. melanogaster
Name
FlyBase ID
FBal0220382
Feature type
allele
Associated gene
Dmel\Ir25a
Associated Insertion(s)
TI{TI}Ir25a1
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Benton et al., 2009)
Mutagen
recombination
(Benton et al., 2009)
gene targeting by homologous recombination
(Benton et al., 2009)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ir25a1
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults with homozygous Ir25a1 have proboscis extension rates that are significantly reduced in response to fatty acids, but not in response to sucrose, compared to controls.

      (Ahn et al., 2017)

      In olfactory preference assays for polyamines, Ir25a1/Ir25a1 flies do not show any significant difference in their attraction to putrescine or cadaverine, as compared to wild type, and females do not show any significant difference in their aversion to oviposit on polyamine-rich substrate (plain, sugar-free 1% agarose supplemented with either putrescine or cadaverine) versus non-supplemented substrate, as compared to wild type.

      (Hussain et al., 2016)

      Ir25a2/Ir25a1 adults have a reduced phase-shift in circadian locomotor activity, compared to controls, when light-dark entrained flies are moved to dark-dark with 7 h advanced 25[o] C:27 [o]C temperature cycles.

      (Chen et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ir25a1 is rescued by Scer\GAL4Gr64f.9.7/Ir25aUAS.cAa

      (Ahn et al., 2017)

      Ir25a2/Ir25a1 is rescued by Ir25a+tCH322-32C20

      (Chen et al., 2015)
      Partially rescued by

      Ir25a1 is partially rescued by Scer\GAL4Ir25a.PA/Ir25aUAS.cAa

      (Ahn et al., 2017)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Generated by gene targeting at the Ir25a locus.

      (Benton et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (12)