FB2024_03 , released June 25, 2024
Allele: Dmel\scwgbb.PF
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General Information
Symbol
Dmel\scwgbb.PF
Species
D. melanogaster
Name
glass bottom boat promoter construct of Fritsch
FlyBase ID
FBal0248920
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

gbb cis-regulatory sequences drive expression of the scw coding region.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

scwgbb.PF is a suppressor of visible | somatic clone phenotype of gbbD20

scwgbb.PF is a suppressor of visible phenotype of Dp(2;2)DTD48, gbb4

scwgbb.PF is a suppressor | partially of lethal phenotype of gbbD20/gbb4

NOT Suppressor of
Statement
Reference

sax1, scwgbb.PF, sax2 is a non-suppressor of visible phenotype of gbb4/gbb1

scwgbb.PF/cv43 is a non-suppressor of visible phenotype of Dp(2;2)DTD48, gbb4

Phenotype Manifest In
Suppressor of
NOT Suppressor of
Statement
Reference

sax1, scwgbb.PF, sax2 is a non-suppressor of wing vein phenotype of gbb4/gbb1

Additional Comments
Genetic Interactions
Statement
Reference

The reduced wing size and vein L5 truncation seen in flies carrying homozygous gbbD20 clones in the anterior compartment of the wing are suppressed by scwgbb.PF; the wing is nearly normal in size and vein L5 reaches the wing margin.

The loss of the posterior crossvein and loss of the distal tip of vein L5 which are seen in flies carrying homozygous gbbD20 clones in the posterior compartment of the wing are both partially suppressed by a single copy of scwgbb.PF, resulting in a small fragment of posterior crossvein which is detached from both the L4 and L5 veins and an almost complete L5 vein.

A single copy of scwgbb.PF partially rescues the lethality of gbb4/gbbD20 animals (34% of the expected number of adults are recovered) and the loss of posterior crossvein and truncation of L5 that are seen in gbb4/gbbD20 adult escapers are partially restored. Two copies of scwgbb.PF rescue the posterior crossvein and vein L5 phenotypes to nearly wild type.

scwgbb.PF rescues the lethality of gbbD20/Df(2R)bw-S46 animals; lethality is rescued from the larval/pupal stage to the pharate adult, with rare viable escapers.

The loss of posterior crossvein which is seen in Dp(2;2)DTD48, gbb4/gbb4 flies is rescued by a single copy of scwgbb.PF.

The ability of scwgbb.PF to rescue the loss of posterior crossvein which is seen in Dp(2;2)DTD48, gbb4/gbb4 flies is completely suppressed in a cv43 background.

scwgbb.PF cannot rescue the wing vein defects of gbb1/gbb4 flies in a sax1/sax2 background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
scwgbb.PF
Name Synonyms
glass bottom boat promoter construct of Fritsch
Secondary FlyBase IDs
    References (1)