FlyBase Allele Report: Dmel\mip130[HMS00462]

General Information

Symbol

Dmel\mip130^HMS00462

Species

D. melanogaster

Name

FlyBase ID

FBal0248217

Feature type

allele

Associated gene

Dmel\mip130

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00462}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00462}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00462

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of mip130^HMS00462 under the control of Scer\GAL4^nub.PU (using UAS-Dicer2 to enhance the RNAi efficiency) does not cause any apparent adult wing defects.

(Miles et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^nub.PU, mip130^HMS00462, pum^GD14303 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^HMS00785 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^L7 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^j3B6 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, brat^GD7073, mip130^HMS00462 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum^HMS01564 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum³ has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^JF02931 has visible | adult stage phenotype

(Miles et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

Scer\GAL4^nub.PU, mip130^HMS00462, pum^GD14303 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^HMS00785 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^L7 has wing vein | ectopic phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^L7 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^j3B6 has wing vein | ectopic phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^j3B6 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, brat^GD7073, mip130^HMS00462 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum^HMS01564 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum³ has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^JF02931 has wing vein | ectopic phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^JF02931 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, nanos^HMS00785 has wing vein | ectopic phenotype

(Miles et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of mip130^HMS00462 RNAi under the control of Scer\GAL4^nub.PU (using UAS-Dicer to enhance RNAi efficiency) in combination with any of the following: pum^GD14303, pum^HMS01564, pum³, nos^JF02931, nos^j3B6 or brat^GD7073 results in adult wing defects of varying severity (ectopic venation, blistering and/or wing blade deformation). Combination/co-expression with any of these: nos^HMS00785, nos^L7, brat¹ or brat^ts1 has no apparent wing phenotype.