FlyBase Allele Report: Dmel\pum[3]

General Information

Symbol

Dmel\pum³

Species

D. melanogaster

Name

FlyBase ID

FBal0014074

Feature type

allele

Associated gene

Dmel\pum

Associated Insertion(s)

Carried in Construct

Also Known As

pum^ET3

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates oculopharyngeal muscular dystrophy

modeled by Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with pum¹)

(Kim et al., 2012)

visible (with pum⁷)

(Kim et al., 2012)

visible (with pum⁰¹⁶⁸⁸)

(Kim et al., 2012)

visible (with pum^Msc)

(Kim et al., 2012)

Phenotype Manifest In

macrochaeta | ectopic (with pum⁷)

(Kim et al., 2012)

macrochaeta | ectopic (with pum⁰¹⁶⁸⁸)

(Kim et al., 2012)

macrochaeta | ectopic (with pum^Msc)

(Kim et al., 2012)

metathoracic tergum (with pum⁷)

(Kim et al., 2012)

metathoracic tergum (with pum⁰¹⁶⁸⁸)

(Kim et al., 2012)

metathoracic tergum (with pum^Msc)

(Kim et al., 2012)

wing vein | ectopic (with pum¹)

(Kim et al., 2012)

wing vein | ectopic (with pum⁰¹⁶⁸⁸)

(Kim et al., 2012)

wing vein | ectopic (with pum^Msc)

(Kim et al., 2012)

Detailed Description

Statement

Reference

Trans-heterozygotes of pum¹/pum³ display extra wing veins.

Trans-heterozygotes of pum³/pum⁰¹⁶⁸⁸ display extra wing veins and extra macrochaetae on their notum. The penetrance of the notum phenotype is incomplete.

Trans-heterozygotes of pum³/pum^Msc display extra wing veins and extra macrochaetae on their notum. The penetrance of the phenotypes is incomplete.

The notum of pum⁷/pum³ escapers display extra macrochaetae. The penetrance of the notum phenotype is incomplete.

(Kim et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

pum³ is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Suppressor of

Statement

Reference

pum³/pum[+] is a suppressor of visible phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

NOT Suppressor of

Statement

Reference

pum³ is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Other

Statement

Reference

Rbf^HMS03004, Scer\GAL4^nub.PU, pum³ has visible | adult stage phenotype

(Miles et al., 2014)

E2f2^JF02828, Scer\GAL4^nub.PU, pum³ has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip120^HMS00461, pum³ has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum³ has visible | adult stage phenotype

(Miles et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

pum³/pum[+] is a suppressor of wing phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

Other

Statement

Reference

Rbf^HMS03004, Scer\GAL4^nub.PU, pum³ has wing blade phenotype

(Miles et al., 2014)

E2f2^JF02828, Scer\GAL4^nub.PU, pum³ has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip120^HMS00461, pum³ has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum³ has wing blade phenotype

(Miles et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of any of the following: Rbf^HMS03004, E2f2^JF02828, mip130^HMS00462 or mip120^HMS00461 under the control of Scer\GAL4^nub.PU (using UAS-Dicer2 to enhance RNAi efficiency) in the pum³ mutant background results in variable minor adult wing defects.

(Miles et al., 2014)

Xenogenetic Interactions

Statement

Reference

pum³ suppresses the wing posture defects seen upon expression of Hsap\PABPN1^17ala.Act88F.

(Chartier et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3335

Diap1^th-1 st¹ kni^ri-1 p^p pum³ e¹ tll¹/TM3, Sb¹

Kyoto

106986

Diap1^th-1 st¹ kni^ri-1 p^p pum³ e¹ tll¹/TM3, Sb¹

Notes on Origin

Discoverer

Recovered on the basis of failure to complement the maternal phenotype.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

pum³

(Chartier et al., 2015, Miles et al., 2014, Kim et al., 2012)

pum^ET3

(Eichler et al., 2020, Wharton et al., 2018, Kadyrova et al., 2007, Sonoda and Wharton, 1999, Murata and Wharton, 1995, Barker et al., 1992, Tearle and Nusslein-Volhard, 1987)

pum^TE3

(Lin and Spradling, 1997)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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