FB2024_03 , released June 25, 2024
Allele: Dmel\slprUASp.Tag:HA
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General Information
Symbol
Dmel\slprUASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0246984
Feature type
allele
Associated gene
Dmel\slpr
Associated Insertion(s)
Carried in Construct
P{UASp-slpr.WT.HA}
Key Links
Transgenic product class
wild_type
(Garlena et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Garlena et al., 2010)
Mutagen
in vitro construct
(Garlena et al., 2010)
Progenitor genotype
Carried in construct
P{UASp-slpr.WT.HA}
Cytology
Description

UASp regulatory sequences drive expression of wild-type slpr (amino acid residues 1-1148) which is tagged at the C-terminal end with two copies of Tag:HA.

(Garlena et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
slpr
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4pnr-MD237 complete dorsal closure.

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4pnr-MD237 results in adult with a narrowed scutellum and/or loss of scutellar bristles.

      Male flies expressing slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS and raised at 25[o]C show a decrease in survival on exposure to 37[o]C heat shock compared to wild-type controls.

      Flies expressing slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS show a significant increase in median survival age (from 52 to 60 days) compared to wild type.

      (Gonda et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4arm.PS/slprUASp.Tag:HA rescues slprBS06

      (Stronach et al., 2014)

      Scer\GAL4arm.PS/slprUASp.Tag:HA rescues slpr921

      (Stronach et al., 2014)

      Scer\GAL4arm.PS/slprUASp.Tag:HA rescues slprBS06

      (Gonda et al., 2012)
      Partially rescues

      Scer\GAL4arm.PS/slprUASp.Tag:HA partially rescues slprBS06

      (Garlena et al., 2010)

      Scer\GAL4arm.PS/slprUASp.Tag:HA partially rescues slpr3P5

      (Garlena et al., 2010)

      Scer\GAL4arm.PS/slprUASp.Tag:HA partially rescues slpr921

      (Garlena et al., 2010)
      Comments

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS rescues the lethality associated with slprBS06 mutant males.

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS rescues the dorsal closure phenotype seen in slpr921 mutant males. Some embryos exhibit head defects.

      (Stronach et al., 2014)

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS significantly rescues the lethality of slprBS06 animals.

      (Gonda et al., 2012)

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS partially rescues the lethality of slprBS06, slpr921 and slpr3P5 mutants.

      Expression of slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS significantly rescues the severe dorsal open phenotype of slpr921 embryos (the penetrance of the phenotype is reduced from 100% to approximately 10%).

      (Garlena et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slprScer\UAS.P\T.T:Ivir\HA1
      slprUASp.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)