FB2024_03 , released June 25, 2024
Allele: Dmel\msl-1AFG
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General Information
Symbol
Dmel\msl-1AFG
Species
D. melanogaster
Name
FlyBase ID
FBal0246503
Feature type
allele
Associated gene
Dmel\msl-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Prabhakaran and Kelley, 2010)
Progenitor genotype
Cytology
Description

The codons 965 and 967 are changed from AFG to EFF.

(Prabhakaran and Kelley, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:18,685,466..18,685,467 [-]
Nucleotide change:

GGC18685467TTC

Reported nucleotide change:

GG?TT

Amino acid change:

G967F | msl-1-PA; G967F | msl-1-PB

Reported amino acid change:

G967F

Comment:

A double nucleotide substitution in codon 967 causes a Gly to Phe mutation. One of two amino acid substitutions in mutant.

(Prabhakaran and Kelley, 2010, Prabhakaran and Kelley, 2010)
point_mutation
2L:18,685,472..18,685,472 [-]
Nucleotide change:

C18685472A

Reported nucleotide change:

C?A

Amino acid change:

A965E | msl-1-PA; A965E | msl-1-PB

Reported amino acid change:

A965E

Comment:

One of two amino acid substitutions in mutant.

(Prabhakaran and Kelley, 2010, Prabhakaran and Kelley, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      msl-1AFG has little or no effect on the fraction of red eye tissue present in males homozygous for P{GMroX1}75C.

      (Prabhakaran and Kelley, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of P{GMroX1}75C (which carries roX1t4.9) to partially rescue the lethality of roX1ex6/Df(1)52 males is suppressed if the males are also heterozygous for msl-1AFG.

      (Prabhakaran and Kelley, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      msl-1L60

      (Prabhakaran and Kelley, 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      msl-1AFG
      (Prabhakaran and Kelley, 2010)
      msl1AFG
      (Prabhakaran and Kelley, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)