FB2024_03 , released June 25, 2024
Allele: Dmel\msl-1F979Z
Open Close
General Information
Symbol
Dmel\msl-1F979Z
Species
D. melanogaster
Name
FlyBase ID
FBal0246502
Feature type
allele
Associated gene
Dmel\msl-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Prabhakaran and Kelley, 2010)
Progenitor genotype
Cytology
Description

11bp deletion which results in the last 61 amino acid residues of msl-1 being replaced with 25 amino acid residues from another reading frame.

(Prabhakaran and Kelley, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:18,685,419..18,685,429 [-]
Comment:

An 11 bp deletion that causes a frameshift affecting the final 61 aa of msl-1.

(Prabhakaran and Kelley, 2010, Prabhakaran and Kelley, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      msl-1F979Z dominantly increases the fraction of red eye tissue present in males homozygous for P{GMroX1}75C, but does not increase eye pigmentation in females carrying P{GMroX1}75C.

      (Prabhakaran and Kelley, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      P{GMroX1}75C (which carries roX1t4.9) is still able to partially rescue the lethality of roX1ex6/Df(1)52 males if the males are also heterozygous for msl-1F979Z.

      (Prabhakaran and Kelley, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      F979Z
      (Prabhakaran and Kelley, 2010)
      msl-1F979Z
      (Prabhakaran and Kelley, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)