FB2024_03 , released June 25, 2024
Allele: Dmel\trrJF03242
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General Information
Symbol
Dmel\trrJF03242
Species
D. melanogaster
Name
FlyBase ID
FBal0242418
Feature type
allele
Associated gene
Dmel\trr
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03242}
Also Known As
UAS-trr-RNAi, UAS-RNAi-trr, trr RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF03242}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF03242
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  brain cancer
      modeled by prosJF02308
      (Gaultier et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Somatic clones expressing trrJF03242 under the control of Scer\GAL4Tub.PU contain a greater overall number of cells and intestinal stem cells in adult flies compared to controls.

      (Gervais et al., 2019)

      Adult flies expressing trrJF03242 under the control of Scer\GAL4ey.PU have eyes of slightly reduced size and rough phenotype.

      (Kanda et al., 2013)

      Knockdown of trr through expression of trrJF03242 under the control of Scer\GAL4Bx-MS1096 causes a mild phenotype consisting of a mild loss of wing veins and mild upward curvature of the wing.

      (Kleefstra et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      NOT Enhancer of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of trrJF03242 with G9aScer\UAS.cKa overexpression (both under the control of Scer\GAL4Bx-MS1096) results in fully penetrant pupal lethality resulting from necrosis of the entire developing wing tissue.

      (Kleefstra et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      trrJF03242
      Name Synonyms
      Secondary FlyBase IDs
        References (14)