FlyBase Allele Report: Dmel\kug[103C]

General Information

Symbol

Dmel\kug^103C

Species

D. melanogaster

Name

FlyBase ID

FBal0241217

Feature type

allele

Associated gene

Dmel\kug

Associated Insertion(s)

Carried in Construct

Also Known As

fat2^103C

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Viktorinová et al., 2009)

Progenitor genotype

P{EP}GE20158

(Viktorinová et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 2688bp deletion spanning from 2366bp 5' to 319bp 3' of the translation start codon. The deletion removes the coding sequence for amino acid residues 1-107.

(Viktorinová et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:20,006,469..20,009,156 [+]

Comment:

2688bp deletion from 2366bp 5' to 319bp 3' of the translation start codon resulting from the imprecise excision of P{EP}GE20158.

(Viktorinová et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Squarr et al., 2016)

female sterile

(Viktorinová et al., 2009)

viable

(Viktorinová et al., 2009)

Phenotype Manifest In

actin filament bundle | oogenesis

(Squarr et al., 2016)

egg | maternal effect

(Squarr et al., 2016)

egg chamber

(Squarr et al., 2016, Viktorinová et al., 2009)

egg chamber (with kug^58D)

(Viktorinová et al., 2009)

Detailed Description

Statement

Reference

kug^103C mutant females lay abnormally round eggs. Egg chambers in these females show strong defects in the planar polarized basal follicle cell actin cytoskeleton, with actin filaments no longer aligned perpendicular to the A-P axis, in contrast to controls.

(Squarr et al., 2016)

Egg chambers of homozygous females fail to elongate and remain almost spherical until stage 14.

Egg chambers of kug^103C/kug^58D females are not as elongated as wild-type egg chambers at stage 9, but the oocyte nucleus migrates normally to the dorsal anterior corner of the oocyte.

(Viktorinová et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions