UASt regulatory sequences drive expression of the endostatin domain of Mp. Tag:SS(wg) has been inserted at the N-terminal end of the Mp sequences.
A high proportion of embryos expressing mpES.Scer\UAS.T:wg under the control of Scer\GAL4how-24B show a generally defective body morphology. Some of the embryos do not have a recognisable nervous system, while other have a recognisable but disordered nervous system. Of those embryos that have a more normal morphology, pathfinding defects are seen in the ISNb (14.6%) and the ISN (11.5%).
MpES.UAS.Tag:SS(wg)/Scer\GAL4C57 is an enhancer of abnormal neurophysiology | larval stage phenotype of Pi3K68DAH1
MpES.UAS.Tag:SS(wg)/Scer\GAL4egr-GAL4 is a non-suppressor of abnormal neurophysiology | larval stage phenotype of Ada2b1
MpES.UAS.Tag:SS(wg)/Scer\GAL4C57 is an enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of Pi3K68DAH1
MpES.UAS.Tag:SS(wg)/Scer\GAL4egr-GAL4 is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Ada2b1
The ISNb axon guidance defects seen in mpΔC12-25 embryos are rescued to wild type by expression of mpES.Scer\UAS.T:wg under the control of Scer\GAL4how-24B.