FB2024_03 , released June 25, 2024
Allele: Dmel\ensΔC
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General Information
Symbol
Dmel\ensΔC
Species
D. melanogaster
Name
FlyBase ID
FBal0230194
Feature type
allele
Associated gene
Dmel\ens
Associated Insertion(s)
TI{TI}ensΔC
Carried in Construct
Also Known As
enscΔC
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Sung et al., 2008)
ends-out gene targeting
(Sung et al., 2008)
Progenitor genotype
Associated Insertion(s)
TI{TI}ensΔC
Cytology
Description

Sequences from +7077 to +9632 relative to the ens transcription start site have been replaced by a w[+] cassette.

(Sung et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:4,124,918..4,127,473 [-]
Comment:

Sequences between +7077 and +9632 relative to the ens transcription start site are deleted and replaced with a w[+] cassette. The deletion removes most of the carboxy-terminal part of the protein and is 2556 bp in length.

(Sung et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ensΔC fails to complement the myonuclear positioning defect of ensswo.

      (Metzger et al., 2012)

      Oocytes derived from homozygous female germline clones show defects in the positioning of the oocyte nucleus and abnormal F-actin accumulations in the centre of the oocyte are seen. Overall distribution of microtubules and microtubule polarity appears grossly normal in oocytes derived from homozygous female germline clones.

      Eggs laid by homozygous females often show dorsal appendage defects, including missing dorsal appendages and dorsal appendages that are close together or fused.

      (Sung et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      ensΔC has partially lethal phenotype, enhanceable by Khc[+]/Khcunspecified

      (Sung et al., 2008)
      Enhancer of
      Statement
      Reference

      ens[+]/ensΔC is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Khc27/+ ; ensΔC/+ double heterozygous females show some stratification of late oocytes, suggesting a defect in cytoplasmic streaming.

      (Sung et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ensΔC
      (Feuillette et al., 2020, Kikuchi et al., 2018, Metzger et al., 2012, Sung et al., 2008)
      enscΔC
      (Kelliher et al., 2018, Gallaud et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)