Expression of dco^{WT.Scer\UAS.T:Hsap\MYC} (line 45F2B but not line 21M1C) under the control of Scer\GAL4^tim.PU significantly reduces the proportion of adult flies with arrhythmic circadian locomotor activity pattern compared to controls.

Scer\GAL4^Act.PU or Scer\GAL4^tim.PU-driven expression of dco^{WT.Scer\UAS.T:Hsap\MYC} increases viability of UV-irradiated larvae and allows significantly higher proportion of them to pupate (although none actually eclose) compared to dco^{C-ala.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6}-expressing larvae.

Scer\GAL4^tim.Scer\UAS-mediated expression of dco^{WT.Scer\UAS.T:Hsap\MYC} does not produce lethality or any obvious external defects.

Scer\GAL4^Act5C.PI-mediated expression of dco^{WT.Scer\UAS.T:Hsap\MYC} produces normal-looking flies, albeit at lower than expected Mendelian ratios.

Scer\GAL4^tim.PE- or Scer\GAL4^tim.Scer\UAS-mediated expression of dco^{WT.Scer\UAS.T:Hsap\MYC} exhibit almost wild-type periods - there is a tendency for periods to be longer than controls, but at most by under an hour. Many flies show reduced rhythmicity compared to controls, but the reduction is variable over a wide range and may result from indirect effects.