FlyBase Allele Report: Dmel\Bdbt[KK102995]

General Information

Symbol

Dmel\Bdbt^KK102995

Species

D. melanogaster

Name

FlyBase ID

FBal0232143

Feature type

allele

Associated gene

Dmel\Bdbt

Associated Insertion(s)

Carried in Construct

P{KK102995}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102995}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102995

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm, with Scer\GAL4^elav-C155

(Fan et al., 2013)

abnormal locomotor rhythm, with Scer\GAL4^tim.PE

(Fan et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^tim.PE- or Scer\GAL4^elav-C155-mediated expression of Bdbt^KK102995, together with Dcr-2^Scer\UAS.cDa, results in arrhythmic locomotor activity in constant darkness. Scer\GAL4^tim.PE-mediated expression of Bdbt^KK102995, in the absence of Dcr-2^Scer\UAS.cDa, results in longer than normal periods instead of arrhythmicity.

Scer\GAL4^tim.PE-mediated expression of Bdbt^KK102995, together with Dcr-2^Scer\UAS.cDa, results in flies that lack anticipation of the dark-to-light and light-to-dark transitions when kept in light:dark cycles. The normal evening peaks of activity are also missing in these flies.

(Fan et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Bdbt^KK102995, Scer\GAL4^tim.PE has abnormal locomotor rhythm phenotype, enhanceable by dco^{K38R.UAS.Tag:MYC}, Scer\GAL4^tim.PE

(Fan et al., 2013)

Suppressed by

Statement

Reference

Bdbt^KK102995, Scer\GAL4^tim.PE has abnormal locomotor rhythm phenotype, suppressible by dco^{WT.UAS.Tag:MYC}, Scer\GAL4^tim.PE

(Fan et al., 2013)

Other

Statement

Reference

Bdbt^KK102995, Scer\GAL4^tim.PE, dco^{K38R.UAS.Tag:MYC} has short lived phenotype

(Fan et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of dco^{WT.Scer\UAS.T:Hsap\MYC} rescues, whereas co-expression of dco^{K38R.Scer\UAS.T:Hsap\MYC} worsens, the locomotor rhythm defects of Bdbt^KK102995 Scer\GAL4^tim.PE animals in constant darkness. Co-expression of dco^{K38R.Scer\UAS.T:Hsap\MYC} and Bdbt^KK102995 via Scer\GAL4^tim.PE also results in a shortened lifespan.

(Fan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bdbt^KK102995 is rescued by Scer\GAL4^tim.PE/Bdbt^UAS.Tag:FLAG

(Fan et al., 2013)

Comments

Co-expression of Bdbt^{Scer\UAS.T:Zzzz\FLAG} rescues the locomotor rhythm defects of Bdbt^KK102995 Scer\GAL4^tim.PE animals in constant darkness.

(Fan et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100028

P{KK102995}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bdbt^KK102995

CG17282^KK102995

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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