FlyBase Allele Report: Dmel\mwh[6]

General Information

Symbol

Dmel\mwh⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0220990

Feature type

allele

Associated gene

Dmel\mwh

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

heat sensitive hypomorphic allele - genetic evidence

(Yan et al., 2008)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: C222Y.

(Yan et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:1,230,445..1,230,445 [+]

Nucleotide change:

G1230445A

Amino acid change:

C222Y | mwh-PA; C454Y | mwh-PB; C455Y | mwh-PC

Reported amino acid change:

C222Y

(Yan et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | heat sensitive

(Yan et al., 2008)

visible | heat sensitive

(Yan et al., 2009)

visible | heat sensitive (with mwh¹)

(Yan et al., 2009)

Phenotype Manifest In

wing hair | heat sensitive

(Yan et al., 2008)

wing hair | increased number

(Fagan et al., 2014)

wing hair | increased number (with mwh¹)

(Fagan et al., 2014)

wing hair | increased number | heat sensitive

(Yan et al., 2009, Yan et al., 2008)

wing hair | increased number | heat sensitive (with mwh¹)

(Yan et al., 2009)

Detailed Description

Statement

Reference

mwh⁶ or mwh¹/mwh⁶ flies show a 'multiple hair cell' phenotype in the wing.

(Fagan et al., 2014)

mwh⁶ animals have a multiple wing hair phenotype that is temperature sensitive; the mean number of hairs/cell is 1.25 at 21[o]C and 1.56 at 25[o]C.

mwh¹/mwh⁶ animals have a multiple wing hair phenotype that is temperature sensitive; the mean number of hairs/cell is 1.83 at 21[o]C and 2.52 at 25[o]C.

(Yan et al., 2009)

Mutant flies raised at 18[o]C show only a weak mutant phenotype, whereas at 29[o]C they show a strong hypomorphic phenotype.

(Yan et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mwh⁶/mwh¹ has visible phenotype, enhanceable by Rho1^unspecified/Rho1[+]

(Yan et al., 2009)

mwh⁶/mwh¹ has visible phenotype, enhanceable by Scer\GAL4^ptc-559.1/RhoGAPp190^UAS.Tag:MYC

(Yan et al., 2009)

Suppressed by

Statement

Reference

mwh⁶/mwh¹ has visible phenotype, suppressible | partially by Scer\GAL4^ap-md544/Rho1^UAS.GFP

(Yan et al., 2009)

mwh⁶/mwh¹ has visible phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Rho1^V14.UAS

(Yan et al., 2009)

mwh⁶/mwh¹ has visible phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/RhoGEF2^UAS.cUa

(Yan et al., 2009)

mwh⁶/mwh¹ has visible phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Rok^CAT.UAS

(Yan et al., 2009)

NOT suppressed by

Statement

Reference

mwh⁶/mwh¹ has visible phenotype, non-suppressible by Scer\GAL4^ptc-559.1/Rok^CAT-KG.UAS

(Yan et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

mwh⁶/mwh¹ has wing hair | increased number phenotype, enhanceable by Rho1^unspecified/Rho1[+]

(Yan et al., 2009)

mwh⁶/mwh¹ has wing hair | increased number phenotype, enhanceable by Scer\GAL4^ptc-559.1/RhoGAPp190^UAS.Tag:MYC

(Yan et al., 2009)

Suppressed by

Statement

Reference

mwh⁶/mwh¹ has wing hair | increased number phenotype, suppressible by cmb^KO

(Fagan et al., 2014)

mwh⁶ has wing hair | increased number phenotype, suppressible by cmb^KO

(Fagan et al., 2014)

mwh⁶/mwh¹ has wing hair | increased number phenotype, suppressible | partially by Scer\GAL4^ap-md544/Rho1^UAS.GFP

(Yan et al., 2009)

mwh⁶/mwh¹ has wing hair | increased number phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Rho1^V14.UAS

(Yan et al., 2009)

mwh⁶/mwh¹ has wing hair | increased number phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/RhoGEF2^UAS.cUa

(Yan et al., 2009)

mwh⁶/mwh¹ has wing hair | increased number phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Rok^CAT.UAS

(Yan et al., 2009)

NOT suppressed by

Statement

Reference

mwh⁶/mwh¹ has wing hair | increased number phenotype, non-suppressible by Scer\GAL4^ptc-559.1/Rok^CAT-KG.UAS

(Yan et al., 2009)

Enhancer of

Statement

Reference

mwh⁶/mwh[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en.PU, cmb^{UAS.RA.Tag:FLAG}

(Fagan et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4^en.PU cmb^Scer\UAS.RA wings.

Homozygosity for cmb^KO significantly suppresses the multiple hair cell phenotype of mwh⁶ and mwh¹/mwh⁶ wings.

(Fagan et al., 2014)

Expression of Rho1^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^ap-md544 weakly suppresses the mwh¹/mwh⁶ multiple wing hair phenotype.

Low levels of expression of Rho1^V14.Scer\UAS under the control of Scer\GAL4^ptc-559.1 at 25[o]C (the flies also carry Scer\GAL80^ts.αTub84B) partially suppress the mwh¹/mwh⁶ multiple wing hair phenotype.

Expression of RhoGEF2^Scer\UAS.cUa under the control of Scer\GAL4^ptc-559.1 partially suppresses the mwh¹/mwh⁶ multiple wing hair phenotype.

The mwh¹/mwh⁶ multiple wing hair phenotype is dominantly enhanced by Rho1^unspecified.

Expression of RhoGAPp190^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ptc-559.1 enhances the mwh¹/mwh⁶ multiple wing hair phenotype.

Expression of rok^CAT.Scer\UAS under the control of Scer\GAL4^ptc-559.1 partially suppresses the mwh¹/mwh⁶ multiple wing hair phenotype.

Expression of rok^{CAT-KG.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 does not suppress the mwh¹/mwh⁶ multiple wing hair phenotype.

(Yan et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66524

w^*; mwh⁶

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG43772⁶

mwh⁶

(Fagan et al., 2014, Yan et al., 2009, Yan et al., 2008)

mwh^ts

(Yan et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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