FlyBase Allele Report: Dmel\XNP[3]

General Information

Symbol

Dmel\XNP³

Species

D. melanogaster

Name

FlyBase ID

FBal0220140

Feature type

allele

Associated gene

Dmel\XNP

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Bassett et al., 2008)

Progenitor genotype

P{EP}XNP^EP635

(Bassett et al., 2008)

Cytology

Description

Imprecise excision of the P{EP}XNP^EP635 insertion, resulting in a 768bp deletion that includes the XNP start codon and the first 105 amino acids of the coding region.

(Bassett et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die

(Bassett et al., 2008)

partially lethal - majority die (with XNP¹)

(López-Falcón et al., 2014)

partially lethal - majority live (with XNP²)

(López-Falcón et al., 2014)

suppressor of variegation, with In(3L)BL1

(López-Falcón et al., 2014)

suppressor of variegation, with P{hsp26-pt-T}39C-12

(Bassett et al., 2008)

suppressor of variegation | dominant, with In(1)w^m4h

(Bassett et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

XNP¹/XNP³ or XNP²/XNP³ flies have reduced viability and no melanotic masses (XNP¹/+, XNP²/+ or XNP³/+ flies are viable and have no melanotic masses).

XNP³ suppresses variegation of the Ecol\lacZ reporter carried on In(3L)BL1.

(López-Falcón et al., 2014)

Homozygous females produce a limited amount of eggs that nevertheless hatch.

Paternal chromatin assembly occurs normally in eggs derived from XNP²/XNP³ females.

(Orsi et al., 2013)

Homozygous flies show a significant reduction in viability at both pupal and adult stages compared to controls.

(Bassett et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

In(3L)BL1, XNP³ has suppressor of variegation phenotype, enhanceable by ADD1^NP0793/ADD1[+]

(López-Falcón et al., 2014)

Enhancer of

Statement

Reference

XNP³/XNP[+] is an enhancer of suppressor of variegation phenotype of ADD1^NP0793, In(3L)BL1

(López-Falcón et al., 2014)

NOT Suppressor of

Statement

Reference

XNP³ is a non-suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of BRWD3^s5349

(Chen et al., 2015)

Other

Statement

Reference

Su(var)205², XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP¹/XNP³ has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP³ has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1[+]/ADD1^NP1240, Su(var)205², XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP²/XNP³ has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

XNP³ is a non-suppressor of eye | somatic clone phenotype of BRWD3^s5349

(Chen et al., 2015)

Other

Statement

Reference

Su(var)205², XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP¹/XNP³ has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP³ has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1[+]/ADD1^NP1240, Su(var)205², XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP²/XNP³ has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous XNP³ fails to suppress the cell lethality seen in BRWD3^s5349 mutant eye clones.

(Chen et al., 2015)

XNP³ or ADD1^NP0793 suppresses variegation of the Ecol\lacZ reporter carried on In(3L)BL1; this suppression is further enhanced in ADD1^NP0793/+;XNP³/+ flies.

(López-Falcón et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26644

w^*; XNP³/TM6B, Tb⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

XNP³

(Chen et al., 2015)

atrx³

(López-Falcón et al., 2014)

dATRX³

(Bassett et al., 2008)

dxnp³

(Chavez et al., 2017)

xnp³

(Meyer-Nava et al., 2020, Orsi et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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