FlyBase Allele Report: Dmel\Cap-H2[Z3-5163]

General Information

Symbol

Dmel\Cap-H2^Z3-5163

Species

D. melanogaster

Name

FlyBase ID

FBal0219643

Feature type

allele

Associated gene

Dmel\Cap-H2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hartl et al., 2008)

Progenitor genotype

Cytology

Description

Disruption of the 5' region of the gene, which is likely to be either an insertion or a rearrangement.

(Hartl et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle (with Cap-H2^TH1)

(Hartl et al., 2008)

abnormal meiotic cell cycle (with Cap-H2^Z3-0019)

(Hartl et al., 2008)

fertile (with Cap-H2^TH1)

(Hartl et al., 2008)

fertile (with Df(3R)Exel6159)

(Hartl et al., 2008)

male semi-fertile (with Cap-H2^Z3-0019)

(Hartl et al., 2008)

male sterile (with Cap-H2^TH1)

(Hartl et al., 2008)

Phenotype Manifest In

polytene chromosome & nurse cell (with Cap-H2^Z3-0019)

(Hartl et al., 2008)

polytene chromosome & nurse cell (with Df(3R)Exel6159)

(Hartl et al., 2008)

Detailed Description

Statement

Reference

Cap-H2^Z3-5163 mutants are fertile as homozygotes and in trans-combinations with Cap-H2^Z3-0019, Df(3R)Exel6159 or Cap-H2^TH1.

Sex chromosome nondisjunction is not found in Cap-H2^Z3-0019/Cap-H2^Z3-5163 mutants.

Fourth chromosome segregation does not differ substantially between Cap-H2^Z3-0019/Cap-H2^Z3-5163 and Cap-H2^Z3-0019 heterozygous control males.

Cap-H2^Z3-0019/Cap-H2^Z3-5163 mutants exhibit an elevated level of exceptional progeny where the second or third chromosomes are exceptional. in both cases the exceptional class most over represented are those from fertilization events involving sperm that lack a 2nd or 3rd chromosome.

Cap-H2^Z3-0019/Cap-H2^Z3-5163 mutants exhibit meiosis I nondisjunction. There may also be a slight increase in meiosis II nondisjunction.

(Hartl et al., 2008)

Polyteny persists in 100% of the nurse cells in stage 10 egg chambers of Cap-H2^Z3-0019/Cap-H2^Z3-5163 and Cap-H2^Z3-0019/Df(3R)Exel6159 females (in contrast to wild-type nurse cells, which disassemble their polytene chromosomes during mid-oogenesis).

(Hartl et al., 2008)

Cap-H2^Z3-5163 has no dominant effect on position effect variegation at the w locus caused by In(1)w^m4h.

(Sweeney et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Cap-H2^Z3-5163/Cap-H2^Z3-0019 has male semi-fertile phenotype, enhanceable by glu[+]/glu^k08819

(Hartl et al., 2008)

Suppressor of

Statement

Reference

Cap-H2^Z3-5163/Cap-H2^Z3-0019 is a suppressor | partially of visible | adult stage phenotype of eya^E4/eya²

(Tian et al., 2019)

Cap-H2^Z3-5163/Cap-H2^Z3-0019 is a suppressor | partially of abnormal size | adult stage phenotype of eya^E4/eya²

(Tian et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cap-H2^Z3-5163/Cap-H2^Z3-0019 is a suppressor | partially of eye phenotype of eya^E4/eya²

(Tian et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

A glu^k08819 heterozygous background lead to a substantial decrease in fertility for Cap-H2^Z3-5163/Cap-H2^Z3-0019 mutants.

(Hartl et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Cap-H2^Z3-0019

(Hartl et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cap-H2⁵¹⁶³

(Tian et al., 2019)

Cap-H2^Z3-5163

(Hartl et al., 2008, Hartl et al., 2008, Hartl et al., 2008)

Z3-5163

(Sweeney et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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