FlyBase Allele Report: Dmel\Msp300[compl]

General Information

Symbol

Dmel\Msp300^compl

Species

D. melanogaster

Name

FlyBase ID

FBal0218042

Feature type

allele

Associated gene

Dmel\Msp300

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

Df(2L)Msp300-compl

Cytology

Description

Df(2L)Msp-300-compl removes the whole Msp-300 locus, along with the Cyp28d2 putative coding sequence, between the insertions P{XP}d07933 and PBac{WH}f05524.

(Technau and Roth, 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage

(Technau and Roth, 2008)

some die during larval stage

(Technau and Roth, 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Myonucleus positioning appears normal in the DA1, DO1, DA2 and DO2 dorsal muscles of Msp-300^compl stage 16 mutant embryos.

(Elhanany-Tamir et al., 2012)

Msp-300^compl homozygotes are larval lethal. They do not display any obvious phenotype and move normally. Over time, the movements become slower and the larvae die before entering the second instar. There is no detectable difference in the arrangement or the movement of the body wall muscles of wild-type and mutant individuals when observing the larvae in polarised light.

Msp-300^compl germline clones lay normal eggs, with no observable defects in nuclear position or nuclear architecture in the egg chambers.

Msp-300^compl mutant cell clones do not cause defects in the eye imaginal disc.

(Technau and Roth, 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Msp300^compl/Msp300[+] is a suppressor | partially of increased cell death | somatic clone | oogenesis phenotype of kud^KO

(Ding et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Msp300^compl is a non-enhancer of eye phenotype of klar^marb-BX12

(Technau and Roth, 2008)

Suppressor of

Statement

Reference

Msp300^compl/Msp300[+] is a suppressor | partially of follicle cell | somatic clone | oogenesis phenotype of kud^KO

(Ding et al., 2017)

Other

Statement

Reference

Msp300^compl, klar^Δ1-18 has embryonic/larval muscle system | third instar larval stage phenotype

(Elhanany-Tamir et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Msp300^compl heterozygosity partially suppresses the increased apoptosis observed in kud^KO homozygous follicular epithelium clones.

(Ding et al., 2017)

In Msp-300^compl klar^Δ1-18 double heterozygous third instar larvae the myonuclei are aberrantly positioned but, as in wild type, they are still associated with the acto-myosin network.

(Elhanany-Tamir et al., 2012)

Female Msp-300^compl;klar^marb-BX12 double mutants lay normal eggs and exhibit wild-type egg chambers. In addition, no defects are found in Msp-300^compl mutant follicle cell clones generated in klar^marb-BX12 homozygous mutant females.

Msp-300^compl;klar^marb-BX12 mutants do not exhibit any morphological alterations in the nuclei of nurse cells or in the oocyte.

Induction of Msp-300^compl mutant cell clones in a klar^marb-BX12 homozygous mutant background in the wing imaginal discs does not affect nuclear positioning.

Msp-300^compl mutant cell clones do not enhance the klar^marb-BX12 mutant rough eye phenotype.

Msp-300^compl;klar^marb-BX12 double mutants do not exhibit any difference in nuclear morphology (or localisation) at any time point during early embryogenesis.

(Technau and Roth, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Msp300^sz75

(Technau and Roth, 2008)

Comments

A Dp(2;1)B19 background rescues the lethality of Msp-300^compl mutants.

(Technau and Roth, 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Df(2L)Msp-300-compl

(Technau and Roth, 2008)

MSP-300^complt

(Elhanany-Tamir et al., 2012)

Msp-300^coml

(Elhanany-Tamir et al., 2012)

Msp-300^compl

Msp300^compl

msp300^compl

(Ding et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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