FlyBase Allele Report: Dmel\Cul3[mds1]

General Information

Symbol

Dmel\Cul3^mds1

Species

D. melanogaster

Name

FlyBase ID

FBal0217813

Feature type

allele

Associated gene

Dmel\Cul3

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lindsley et al., 2013, Roote, 2008.8.22)

Progenitor genotype

Cytology

Description

181bp deletion that eliminates part of the 5'UTR of the cul-3 testis isoform.

(Arama et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male fertile (with Cul3⁰⁶⁴³⁰)

(Arama et al., 2007)

male sterile

(Arama et al., 2007)

male sterile (with Cul3^d577)

(Arama et al., 2007, Arama et al., 2007)

male sterile (with Cul3^gft1)

(Arama et al., 2007, Arama et al., 2007)

male sterile (with Cul3^gft2)

(Roote, 2008.8.22, Arama et al., 2007, Arama et al., 2007)

male sterile (with Cul3^gft3)

(Arama et al., 2007)

male sterile (with Cul3^gft4)

(Arama et al., 2007)

male sterile (with Cul3^GR18)

(Arama et al., 2007, Arama et al., 2007)

Phenotype Manifest In

spermatid (with Cul3^gft1)

(Arama et al., 2007)

spermatid (with Cul3^gft2)

(Arama et al., 2007)

spermatid (with Cul3^gft4)

(Arama et al., 2007)

spermatid (with Cul3^GR18)

(Arama et al., 2007)

Detailed Description

Statement

Reference

cul-3^mds1/cul-3^gft2, cul-3^mds1/cul-3^GR18, cul-3^mds1/cul-3^gft1 and cul-3^mds1/cul-3^gft4 spermatids show defects in individualisation.

(Arama et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Cul3^mds1/Cul3[+] is a non-suppressor of abnormal size phenotype of Scer\GAL4^GMR.PS, klhl10^UAS.cKa

(Aram et al., 2016)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Cul3^mds1/Cul3[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PS, klhl10^UAS.cKa

(Aram et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Cul3^mds1/+ fails to rescue the reduced eye phenotype of flies expressing klhl10^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PS.

(Aram et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Cul3⁰⁶⁴³⁰

(Arama et al., 2007)

Fails to complement

Cul3^gft4

(Arama et al., 2007)

Cul3^gft3

(Arama et al., 2007)

Cul3^gft1

(Arama et al., 2007)

Cul3^d577

(Arama et al., 2007)

Cul3^GR18

(Arama et al., 2007)

Rescued by

Cul3^mds1 is rescued by Cul3^Testis

(Arama et al., 2007)

Not rescued by

Cul3^mds1 is not rescued by Cul3^Soma

(Arama et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25147

Cul3^mds1 cn¹ bw¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Cul-3^mds1

Cul3^mds1

Z1089

(Lindsley et al., 2013)

Z2-1089

(Arama et al., 2007)

cul-3^mds1

cul3_Testis

(Kaplan et al., 2010)

cul3^mds1

(Aram et al., 2016, Kaplan et al., 2010, Arama et al., 2007, Arama et al., 2007)

gft^Z1089

(Roote, 2008.8.22)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close