FlyBase Allele Report: Dmel\kon[C41]

General Information

Symbol

Dmel\kon^C41

Species

D. melanogaster

Name

FlyBase ID

FBal0217362

Feature type

allele

Associated gene

Dmel\kon

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schnorrer et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: G168D.

(Schnorrer et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:18,495,568..18,495,568 [-]

Nucleotide change:

G18495568A

Amino acid change:

G168D | kon-PB; G168D | kon-PC; G168D | kon-PD

Reported amino acid change:

G168D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Schnorrer et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with kon^A04)

(Schnorrer et al., 2007)

lethal (with kon^A49)

(Schnorrer et al., 2007)

lethal (with kon^C25)

(Schnorrer et al., 2007)

lethal (with kon^C452)

(Schnorrer et al., 2007)

lethal (with kon^C1115)

(Schnorrer et al., 2007)

lethal (with kon^C1139)

(Schnorrer et al., 2007)

lethal (with kon^C2263)

(Schnorrer et al., 2007)

Phenotype Manifest In

muscle cell of A1-7 ventral longitudinal muscle 1

(Schnorrer et al., 2007)

muscle cell of A1-7 ventral longitudinal muscle 1 (with kon^C452)

(Schnorrer et al., 2007)

muscle cell of A1-7 ventral longitudinal muscle 2 (with kon^C452)

(Schnorrer et al., 2007)

muscle cell of A1-7 ventral longitudinal muscle 3 (with kon^C452)

(Schnorrer et al., 2007)

muscle cell of A1-7 ventral longitudinal muscle 4 (with kon^C452)

(Schnorrer et al., 2007)

Detailed Description

Statement

Reference

The four ventral-longitudinal muscles (VL1-4) generally have a rounded morphology and fail to connect to any tendon cell in the abdominal segments of kon^C41/kon^C452 embryos.

Muscle VL1 exhibits a rounded morphology in approximately 50% of cases in kon^C41 embryos. In approximately 30% of the remaining cases, the VL1 muscle fails to span the entire abdominal segment.

(Schnorrer et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions