FlyBase Allele Report: Dmel\spoon[P1]

General Information

Symbol

Dmel\spoon^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0216917

Feature type

allele

Associated gene

Dmel\spoon

Associated Insertion(s)

P{lacW}spoon^P1

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{lacW}spoon^P1

Cytology

Description

P{lacW} insertion in an intron.

(Lu et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory (with spoon^KG02745)

(Lu et al., 2007)

abnormal memory | recessive

(Lu et al., 2007)

viable

(Lu et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

Memory retention in homozygous flies is normal in a Pavlovian olfactory learning assay when measured immediately or 3 hours after one training session. One day memory is normal after massed training, but one-day memory after spaced training is impaired in homozygous flies (and the performance index one day after spaced training is similar to that seen after massed training). This indicates that short-term memory, middle-term memory and anesthesia-resistant memory are normal, but that long-term memory is impaired in the mutant flies.

Sensorimotor responses to octanol and methylcyclohexanol and to foot shock are normal in homozygous flies.

yu^P1/yu^KG02745 flies show defective one-day memory after spaced training in a Pavlovian olfactory learning assay.

(Lu et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Pka-C1^H2, yu[+]/spoon^P1 has abnormal memory | dominant phenotype