Imprecise excision deletion of nucleotides 76208-77847 (GB:AE003701).
Lkb1X5 somatic clones in the follicular epithelium exhibit multilayering in about a third of cases, which is not observed in controls.
lkb1X5 mutant eye disc clones do not show an increase in apoptosis following fasting compared to wild type controls.
Mutant embryos derived from homozygous female germ-line clones contain cells with an excessive DNA content in the nucleus and have epithelial polarity defects.
Mutant larvae have mitotic and epithelial polarity defects.
lkb1X5 mutants die before the mid-pupal stage.
During nerve cord condensation (embryonic stage 16), significantly fewer apoptotic cells are observed, both in the ventral nerve cord and embryonic head of lkb1X5 mutants.
Homozygous lkb1X5 mutant larvae exhibit dramatically enlarged brain hemispheres and ventral ganglion, compared to wild-type.
A small portion (~10%) of lkb1X5 homozygotes exhibit various dorsal-open phenotypes in hatched or unhatched first-instar larvae.
Lkb1X5 has abnormal mitotic cell cycle phenotype, suppressible by sqhE20.E21
Lkb1X5 has abnormal mitotic cell cycle phenotype, suppressible by AMPKαTD.UAS/Scer\GAL4hs.PB
Lkb1X5 has abnormal cell polarity phenotype, suppressible by AMPKαTD.UAS/Scer\GAL4hs.PB
Lkb1X5 has abnormal cell polarity phenotype, suppressible by sqhE20.E21
Lkb1X5 has decreased cell death phenotype, suppressible by hepAct.UAS/Scer\GAL4hs.PB
Lkb1X5 is an enhancer of abnormal starvation stress response | somatic clone phenotype of Axn127
Lkb1X5 is an enhancer of increased cell death | somatic clone | nutrition conditional phenotype of Axn127
Lkb1X5 is an enhancer of increased cell death | somatic clone phenotype of AxnS044230, Rbf15aΔ
Lkb1X5 is a suppressor of abnormal cell polarity | somatic clone phenotype of Vps155
Lkb1X5 is a suppressor | somatic clone of neoplasia | somatic clone | larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, Vps155
Lkb1X5 is a suppressor | somatic clone of abnormal developmental rate phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, Vps155
Lkb1X5 is a suppressor of neoplasia | somatic clone | larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI
Lkb1X5, Scer\GAL4e22c is a suppressor of increased cell death phenotype of Scer\GAL4e22c, Sln6.UAS.Tag:MYC
lkb1[+]/Lkb1X5 is a non-suppressor of increased cell death phenotype of Scer\GAL4GMR.PF, egrUAS.cLa
Lkb1X5 has follicle cell | somatic clone phenotype, non-enhanceable by Vps155
Lkb1X5 has embryonic/larval brain phenotype, suppressible by hepAct.UAS/Scer\GAL4hs.PB
Lkb1X5 has larval ventral nerve cord phenotype, suppressible by hepAct.UAS/Scer\GAL4hs.PB
Lkb1X5 is an enhancer of eye disc | somatic clone | nutrition conditional phenotype of Axn127
Lkb1X5 is an enhancer of eye disc | somatic clone phenotype of AxnS044230, Rbf15aΔ
Lkb1X5 is a suppressor of follicle cell | somatic clone phenotype of Vps155
Lkb1X5 is a suppressor | somatic clone of eye-antennal disc | somatic clone | larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, Vps155
Lkb1X5 is a suppressor of eye-antennal disc | somatic clone | larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI
Lkb1X5, Scer\GAL4e22c is a suppressor of wing disc phenotype of Scer\GAL4e22c, Sln6.UAS.Tag:MYC
Vps155, Lkb1X5 double mutant somatic clones in the follicular epithelium exhibit multilayering at a frequency similar to that of Lkb1X5 single clones rather than the high frequency observed in Vps155 single clones. The mis-localization of cell polarity markers presented by Vps155 homozygous follicle cell clones is also suppressed by Lkb1X5 homozygosity in the clones.
The moderate overgrowth of eye-antennal discs bearing clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.PI is suppressed by Lkb1X5 homozygosity in the clones.
The severe eye-antennal disc tumor phenotype and delayed pupation resulting from larval eye-antennal disc clones both homozygous for Vps155 and expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.PI are both suppressed by additional Lkb1X5 homozygosity in the clones.
Scer\GAL4e22c Sln6.Scer\UAS.T:Hsap\MYC-mediated apoptosis upon butyrate treatment is considerably suppressed in a lkb1X5 mutant background.
The epithelial polarity defects and genomic instability seen in lkb1X5 larvae are suppressed by expression of SNF1ATD.Scer\UAS under the control of Scer\GAL4hs.PB.
The epithelial polarity defects and genomic polyploidy defects seen in lkb1X5 larvae are suppressed by sqhE20.E21.
Ectopic activation of JNK signaling by overexpression of hepAct.Scer\UAS (under the control of Scer\GAL4hs.PB) completely rescues the 'big brain' phenotype of lkb1X5 mutants and restores embryonic apoptosis.
Trans-heterozygotic combinations between lkb1X5 and bsk1 or bsk2 induces significant dorsal open phenotypes in unhatched first instar larvae.
Dosage reduction of lkb1X5 does not affect Scer\GAL4GMR.PF; egrScer\UAS.cla induced apoptosis.
Lkb1X5 is rescued by Lkb1UAS.cLa/Scer\GAL4hs.PB
Transgenic expression of lkb1Scer\UAS.cLa using a Scer\GAL4hs.PB driver successfully rescues the lethality of lkb1X5 mutants.
Ectopic expression of lkb1Scer\UAS.cLa under the control of Scer\GAL4hs.PB successfully suppresses the 'big brain' phenotype observed in lkb1X5 mutants.