FlyBase Allele Report: Dmel\Neurl4[GD11930]

General Information

Symbol

Dmel\Neurl4^GD11930

Species

D. melanogaster

Name

FlyBase ID

FBal0209155

Feature type

allele

Associated gene

Dmel\Neurl4

Associated Insertion(s)

Carried in Construct

P{GD11930}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11930}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11930

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Neurl4^GD11930 under the control of Scer\GAL4^ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) does not affect the number dopaminergic neurons in the PPM1/2 cluster in the adult brain.

(Imai et al., 2015)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11930

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor | partially of abnormal flight phenotype of Hsap\LRRK2^RG.UAS, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of decreased cell number | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\LRRK2^RG.UAS, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\LRRK2^RG.UAS, Scer\GAL4^ple.PU

(Imai et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of dopaminergic PPM1 neuron | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of dopaminergic PPM2 neuron | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor of dopaminergic PPM3 neuron | adult stage phenotype of Delta^UAS.cUa, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor | partially of dopaminergic PPM1 neuron | adult stage phenotype of Hsap\LRRK2^RG.UAS, Scer\GAL4^ple.PU

(Imai et al., 2015)

Neurl4^GD11930, Scer\GAL4^ple.PU is a suppressor | partially of dopaminergic PPM2 neuron | adult stage phenotype of Hsap\LRRK2^RG.UAS, Scer\GAL4^ple.PU

(Imai et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of dopaminergic neurons from the PPL1, PPM1/2 and PPM3 clusters in the adult brain characteristic for flies expressing Dl^Scer\UAS.cUa under the control of Scer\GAL4^ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) can be prevented by co-expression Neurl4^GD11930.

(Imai et al., 2015)

Xenogenetic Interactions

Statement

Reference

The loss of dopaminergic neurons from the PPM1/2 cluster in the adult brain and severe age-dependent decline in flight activity characteristic for flies expressing Hsap\LRRK2^RG.Scer\UAS under the control of Scer\GAL4^ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) is significantly suppressed by co-expression of Neurl4^GD11930.

(Imai et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v27630

w¹¹¹⁸; P{GD11930}v27630/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11930

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG46284^GD11930

Neurl4^GD11930

blue^GD11930

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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