FlyBase Allele Report: Dmel\aux[727]

General Information

Symbol

Dmel\aux⁷²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0197308

Feature type

allele

Associated gene

Dmel\aux

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Eun et al., 2007)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Eun et al., 2007)

Amino acid replacement: W254term.

(Eun et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:4,222,472..4,222,472 [+]

Nucleotide change:

G4222472A

Reported nucleotide change:

G?A

Amino acid change:

W254term | aux-PA; W254term | aux-PB; W254term | aux-PC; W246term | aux-PD

Reported amino acid change:

W254term

Comment:

Reported as a TGG to TAG nonsense mutation.

(Eun et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with aux^D136)

(Eun et al., 2007)

lethal (with aux^F37)

(Eun et al., 2007)

lethal (with aux^L7)

(Eun et al., 2007)

Phenotype Manifest In

eye photoreceptor cell (with aux^D136)

(Eun et al., 2008)

eye photoreceptor cell (with aux^L7)

(Eun et al., 2007)

eye photoreceptor cell | ectopic (with aux^L7)

(Eun et al., 2007)

ommatidium (with aux^L7)

(Eun et al., 2007)

Detailed Description

Statement

Reference

No photoreceptor cells are found in he centre of large aux[-] clones (aux⁷²⁷/aux^D136 cells in a background where the aux⁷²⁷/aux^D136 genotype is rescued by aux^+t21) in third larval instar eye discs and aux[-] photoreceptor cells at the clone borders are disorganised.

Morphogenetic furrow movement inside aux[-] clones (aux⁷²⁷/aux^D136 cells in a background where the aux⁷²⁷/aux^D136 genotype is rescued by aux^αTub84B.PE) in third larval instar eye discs resembles that of wild type.

(Eun et al., 2008)

aux^L7/aux⁷²⁷ escapers have disorganised ommatidia. Many have too many photoreceptor cells, some have too few and some ommatidia are fused.

(Eun et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aux⁷²⁷/aux[+] is an enhancer of visible phenotype of lqf^{glrs.Tag:FLAG}