FlyBase Allele Report: Dmel\santa-maria[1]

General Information

Symbol

Dmel\santa-maria¹

Species

D. melanogaster

Name

FlyBase ID

FBal0196218

Feature type

allele

Associated gene

Dmel\santa-maria

Associated Insertion(s)

Carried in Construct

Also Known As

santa maria¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wang et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: G217D.

(Wang et al., 2007)

Nucleotide substitution: G?A.

(Wang et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:7,446,733..7,446,733 [-]

Nucleotide change:

G7446733A

Reported nucleotide change:

G?A

Amino acid change:

G217D | santa-maria-PA; G217D | santa-maria-PC

Reported amino acid change:

G217D

(Wang et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of sensorineural hearing loss

CEA

(Senthilan et al., 2012)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception | adult stage

(Senthilan et al., 2012)

abnormal neurophysiology

(Katana et al., 2019, Wang et al., 2007)

abnormal neurophysiology | adult stage

(Senthilan et al., 2012)

abnormal thermotaxis | larval stage

(Shen et al., 2011)

abnormal thermotaxis | third instar larval stage

(Sokabe et al., 2016)

viable

(Wang et al., 2007)

Phenotype Manifest In

abdominal lateral pentascolopidial chordotonal organ lch5 | third instar larval stage

(Katana et al., 2019)

Johnston organ | third instar larval stage

(Katana et al., 2019)

Detailed Description

Statement

Reference

santa-maria¹ animals exhibit defects in the function of abdominal lateral pentascolopidial chordotonal organ lch5 (in third instar larvae) and Johnston organ (in adults) mechanoreceptors compared to controls.

(Katana et al., 2019)

santa-maria¹ homozygous mutant third instar larvae show impaired temperature selection and unlike controls display no strong preference for cooler temperatures (18[o]C) in a temperature gradient. This effect is not light-sensitive and does not appear to be due to developmental delay as the mutants enter third instar stage with similar timing as controls.

(Sokabe et al., 2016)

Mechanical and electrical responses to sound in the Johnston's organ are impaired in mutant flies.

(Senthilan et al., 2012)

Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls. This defect is reversed if all trans-retinal is added to the food.

(Shen et al., 2011)

Electroretinograms from santa-maria¹ flies fail to show prolonged depolarization afterpotential (PDA) in response to blue light. This phenotype is rescued when flies are fed with all-trans-retinal but not when they are fed with β-carotene.

(Wang et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

santa-maria¹ has abnormal neurophysiology | third instar larval stage phenotype, non-enhanceable by pinta¹

(Katana et al., 2019)

NOT suppressed by

Statement

Reference

santa-maria¹ has abnormal neurophysiology | third instar larval stage phenotype, non-suppressible by pinta¹

(Katana et al., 2019)

santa-maria¹ has abnormal neurophysiology phenotype, non-suppressible by Scer\GAL4^{santa-maria.PW}/ninaD^UAS.cKa

(Wang et al., 2007)

santa-maria¹ has abnormal neurophysiology phenotype, non-suppressible by Scer\GAL4^{santa-maria.PW}/Hsap\SCARB1^UAS.cWa

(Wang et al., 2007)

Enhancer of

Statement

Reference

santa-maria¹ is an enhancer of abnormal neurophysiology | third instar larval stage phenotype of pinta¹

(Katana et al., 2019)

Suppressor of

Statement

Reference

santa-maria¹ is a suppressor of lethal - all die before end of pupal stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

Other

Statement

Reference

pinta¹, santa-maria¹ has lethal phenotype

(Katana et al., 2019)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

santa-maria¹ has abdominal lateral pentascolopidial chordotonal organ lch5 | third instar larval stage phenotype, non-enhanceable by pinta¹

(Katana et al., 2019)

NOT suppressed by

Statement

Reference

santa-maria¹ has abdominal lateral pentascolopidial chordotonal organ lch5 | third instar larval stage phenotype, non-suppressible by pinta¹

(Katana et al., 2019)

Enhancer of

Statement

Reference

santa-maria¹ is an enhancer of abdominal lateral pentascolopidial chordotonal organ lch5 | third instar larval stage phenotype of pinta¹

(Katana et al., 2019)

Suppressor of

Statement

Reference

santa-maria¹ is a suppressor of embryonic/larval salivary gland phenotype of Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

A santa-maria¹ homozygous mutant background partially suppresses the Ras85D^V12.Scer\UAS-induced overgrowth, including the aberrant histology of the salivary glands and the mortality.

(Hauling et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

santa-maria¹ is rescued by santa-maria^UAS.cWa/Scer\GAL4^NP0761

(Senthilan et al., 2012)

santa-maria¹ is rescued by Scer\GAL4^{santa-maria.PW}/santa-maria^UAS.cWa

(Wang et al., 2007)

santa-maria¹ is rescued by Scer\GAL4^ninaB.PW/santa-maria^UAS.cWa

(Wang et al., 2007)

santa-maria¹ is rescued by santa-maria^UAS.cWa/Scer\GAL4^elav.PLu

(Wang et al., 2007)

santa-maria¹ is rescued by Scer\GAL4^repo/santa-maria^UAS.cWa

(Wang et al., 2007)

Partially rescued by

santa-maria¹ is partially rescued by Scer\GAL4^repo/santa-maria^UAS.cWa

(Katana et al., 2019)

santa-maria¹ is partially rescued by santa-maria^hs.PW

(Wang et al., 2007)

Not rescued by

santa-maria¹ is not rescued by Scer\GAL4^ninaE.PD/santa-maria^UAS.cWa

(Wang et al., 2007)

santa-maria¹ is not rescued by Scer\GAL4^rdhB.PW/santa-maria^UAS.cWa

(Wang et al., 2007)

santa-maria¹ is not rescued by Scer\GAL4^ninaD.PW/santa-maria^UAS.cWa

(Wang et al., 2007)

santa-maria¹ is not rescued by Scer\GAL4^drm.7.1/santa-maria^UAS.cWa

(Wang et al., 2007)

Comments

Expression of santa-maria^Scer\UAS.cWa under the control of Scer\GAL4^ph-p-NP0761 rescues the defects in mechanical and electrical responses of the Johnston's organ to sound which are seen in santa-maria¹ flies.

(Senthilan et al., 2012)

Expression of santa-maria^hs.PW restores a prolonged depolarization afterpotential in response to blue light in electroretinogram recordings from santa-maria¹ flies.

(Wang et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

24520

w^*; santa-maria¹

24519

w^*; santa-maria¹; P{UAS-santa-maria.W}3

Notes on Origin

Discoverer

Selected as: a homozygous viable mutation that causes a defect in electroretinogram recordings in a screen of chromosome 2.

(Wang et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

santa maria¹

(Huang and Ryoo, 2021, Huang et al., 2018, Sokabe et al., 2016, Shen et al., 2011, Wang et al., 2007)

santa-maria¹

(Katana et al., 2019, Zanini et al., 2018, Hauling et al., 2014, Senthilan et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (10)

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