FB2024_03 , released June 25, 2024
Allele: Dmel\γTub23Cbmps4
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General Information
Symbol
Dmel\γTub23Cbmps4
Species
D. melanogaster
Name
FlyBase ID
FBal0196101
Feature type
allele
Associated gene
Dmel\γTub23C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mahoney et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: P358L.

(Mahoney et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,974,249..2,974,249 [+]
Nucleotide change:

C2974249T

Amino acid change:

P358L | gammaTub23C-PA

Reported amino acid change:

P358L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Mahoney et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes have small-to-moderate sized bumps on the wing, usually along the wing vein and show occasional nicking of the wing. They also show a very mild rough eye phenotype that is not highly penetrant.

      The phenotype of bumps on the wing appears to be temperature sensitive; 0-5% of heterozygotes show this phenotype at 18oC or 23oC, while at 27oC, 47% display this phenotype.

      (Mahoney et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      γTub23Cbmps4 is an enhancer of visible phenotype of Psn9/Psn143

      (Mahoney et al., 2006)

      γTub23C[+]/γTub23Cbmps4 is an enhancer of visible | dominant phenotype of DeltaeA7

      (Mahoney et al., 2006)
      Other
      Statement
      Reference

      γTub23Cbmps4, Psn9/Psn143 has visible phenotype

      (Mahoney et al., 2006)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      γTub23Cbmps4 is an enhancer of eye phenotype of Psn9/Psn143

      (Mahoney et al., 2006)

      γTub23C[+]/γTub23Cbmps4 is an enhancer of wing vein phenotype of DeltaeA7

      (Mahoney et al., 2006)

      γTub23C[+]/γTub23Cbmps4 is an enhancer of wing vein | ectopic phenotype of DeltaeA7

      (Mahoney et al., 2006)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      γTub23Cbmps4 ; Psn9/Psn143 flies have bumps and notching on the wing and wing vein thickening. The double heterozygous flies have ectopic veins on the wing.

      γTub23Cbmps4/+ enhances the wing notching and wing vein thickening seen in Df(1)N-81k1/+ flies.

      γTub23Cbmps4/+ enhances the wing vein thickening and amount of ectopic wing vein seen in DleA7/+ flies.

      (Mahoney et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bmps4
      (Mahoney et al., 2006)
      γTub23Cbmps4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)