FlyBase Allele Report: Dmel\Wnt5[GS1192]

General Information

Symbol

Dmel\Wnt5^GS1192

Species

D. melanogaster

Name

FlyBase ID

FBal0194959

Feature type

allele

Associated gene

Dmel\Wnt5

Associated Insertion(s)

P{GSV1}Wnt5^GS1192

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV1}Wnt5^GS1192

Cytology

Description

Insertion oriented to drive expression in the sense direction starting upstream of the coding region.

(Gregory et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{GSV1}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:18,505,449..18,505,449

(Sakurai et al., 2009, Gregory et al., 2007, Yao et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^SG18.1

(Yao et al., 2007)

Phenotype Manifest In

adult antennal lobe, with Scer\GAL4^SG18.1

(Yao et al., 2007)

adult antennal lobe commissure, with Scer\GAL4^SG18.1

(Yao et al., 2007)

Detailed Description

Statement

Reference

Expression of Wnt5^GS1192 under the control of Scer\GAL4^SG18.1 results in malformed antennal lobes. Glomerulus-like structures are seen in the commissure in 79% of antennal lobes, enlarging it to approximately 60μm in thickness.

(Yao et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^AM29, Wnt5^GS1192, drl^R343 has abnormal neuroanatomy phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Scer\GAL4^AM29, Wnt5^GS1192 has abnormal neuroanatomy phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Enhancer of

Statement

Reference

Scer\GAL4^AM29/Wnt5^GS1192 is an enhancer of abnormal neuroanatomy phenotype of drl^R343

(Sakurai et al., 2009)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Wnt5^GS1192 is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^AM29, Wnt5^GS1192, drl^R343 has glomerulus phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Scer\GAL4^AM29, Wnt5^GS1192, drl^R343 has antennal lobe phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Scer\GAL4^AM29, Wnt5^GS1192, drl^R343 has olfactory receptor neuron phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Scer\GAL4^AM29, Wnt5^GS1192 has glomerulus phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Scer\GAL4^AM29, Wnt5^GS1192 has antennal lobe phenotype, suppressible by Drl-2^E124

(Sakurai et al., 2009)

Enhancer of

Statement

Reference

Scer\GAL4^AM29/Wnt5^GS1192 is an enhancer of antennal lobe phenotype of drl^R343

(Sakurai et al., 2009)

Scer\GAL4^AM29/Wnt5^GS1192 is an enhancer of olfactory receptor neuron phenotype of drl^R343

(Sakurai et al., 2009)

Scer\GAL4^AM29/Wnt5^GS1192 is an enhancer of glomerulus phenotype of drl^R343

(Sakurai et al., 2009)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Wnt5^GS1192 is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Wnt5^GS1192 in drl^R343 mutant olfactory receptor neurons (under the control of Scer\GAL4^AM29) severely affects axonal projections; olfactory receptor neuron axons target ectopic regions near the original antennal lobe positions, enhancing the drl^R343 mutant phenotype. This enhancement is ameliorated through the loss of Drl-2 in Drl-2^E124 mutants. Olfactory receptor neuron axons project to the normal antennal lobe positions in these triple mutants. The glomerular pattern is similar to that of drl^R343 Drl-2^E124 double mutants.

(Sakurai et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

200177

y¹ w^67c23 P{GSV1}Wnt5^GS1192/Binsinscy

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Wnt5^GS1192

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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