FB2024_03 , released June 25, 2024
Allele: Dmel\Diap1RNAi.UAS.cOa
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General Information
Symbol
Dmel\Diap1RNAi.UAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0194834
Feature type
allele
Associated gene
Dmel\Diap1
Associated Insertion(s)
Carried in Construct
P{UAS-DIAP1.RNAi.O}
Key Links
Transgenic product class
RNAi_reagent
(Oshima, 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Oshima, 2006)
Mutagen
in vitro construct
(Oshima, 2006)
Progenitor genotype
Carried in construct
P{UAS-DIAP1.RNAi.O}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a Diap1 fragment.

(Oshima, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Diap1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of thdsRNA.cOa.Scer\UAS in all four cells of the adult sensory organ, under the control of Scer\GAL4sca-109-68, thereby resulting in a down-regulation of th, results in bristle loss, but sockets show normal development.

      (Koto et al., 2009)

      Expression of thdsRNA.cOa.Scer\UAS under the control of Scer\GAL4ap-md544 does not lead to an increase in the number of apoptotic cells observed in eye/antennal discs.

      (Oshima, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The excess branching of arista seen in flies that express ik2DN.Scer\UAS under the control of Scer\GAL4ap-md544 is suppressed by thdsRNA.cOa.Scer\UAS.

      (Oshima et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Diap1RNAi.UAS.cOa is rescued by Diap1PRAP.UAS.Venus/Scer\GAL4sca-109-68

      (Koto et al., 2009)
      Comments

      The loss-of-bristle phentoype observed in thdsRNA.cOa.Scer\UAS-Scer\GAL4sca-109-68 flies is suppressed though expression of thN117K.H283Y.Scer\UAS.T:Avic\GFP-YFP.Venus.

      (Koto et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transcription from P{UAS-DIAP1.dsRNA} should produce th dsRNA, resulting in dsRNA interference (RNAi) of the th gene.

      (Oshima, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      DAIP1RNAi
      (Oshima et al., 2006)
      Diap1RNAi.UAS.cOa
      Diap1dsRNA.cOa.Scer\UAS
      Diap1dsRNA.cOa.UAS
      thdsRNA.cOa.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)