FlyBase Allele Report: Dmel\Delta[EP3816.A]

General Information

Symbol

Dmel\Delta^EP3816.A

Species

D. melanogaster

Name

FlyBase ID

FBal0194268

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

P{EP}Delta^EP3816.A

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Alexander et al., 2006)

Mutagen

Delta2-3 transposase

(Alexander et al., 2006)

Progenitor genotype

Associated Insertion(s)

P{EP}Delta^EP3816.A

Cytology

Description

The P{EP} element disrupts intron 1 of the Dl gene, approximately 1.8 kb 5' to the start of exon 2.

(Alexander et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | neurogenic phenotype

(Alexander et al., 2006)

visible | adult stage | dominant

(Alexander et al., 2006)

Phenotype Manifest In

embryonic/larval neuron

(Alexander et al., 2006)

wing vein

(Alexander et al., 2006)

Detailed Description

Statement

Reference

Flies heterozygous for Dl^EP3816.A alone or for both Dl^EP3816.A and Scer\GAL4^C96 show wing vein thickening.

Dl^EP3816.A embryos show a neural hypertrophy phenotype.

(Alexander et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Delta^EP3816.A, Scer\GAL4^bbg-C96 is an enhancer of visible | adult stage phenotype of Scer\GAL4^bbg-C96, mam^H.UAS

(Alexander et al., 2006)

Delta^EP3816.A, Scer\GAL4³⁰⁹ is an enhancer of visible | adult stage phenotype of Scer\GAL4³⁰⁹, mam^H.UAS

(Alexander et al., 2006)

Delta^EP3816.A, Scer\GAL4^pnr-MD237 is an enhancer of visible | adult stage phenotype of Scer\GAL4^pnr-MD237, mam^N.UAS

(Alexander et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

Delta^EP3816.A, Scer\GAL4^bbg-C96 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, mam^H.UAS

(Alexander et al., 2006)

Delta^EP3816.A, Scer\GAL4³⁰⁹ is an enhancer of posterior notopleural bristle phenotype of Scer\GAL4³⁰⁹, mam^H.UAS

(Alexander et al., 2006)

Delta^EP3816.A, Scer\GAL4^pnr-MD237 is an enhancer of mesothoracic tergum & microchaeta phenotype of Scer\GAL4^pnr-MD237, mam^N.UAS

(Alexander et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The wing margin nicking phenotype produced by expression of mam^H.Scer\UAS under the control of Scer\GAL4^C96 is slightly enhanced in flies heterozygous for Dl^EP3816.A, though the phenotypic effects are largely additive.

The notal microchaete loss phenotype induced by expression of mam^N.Scer\UAS under the control of Scer\GAL4^pnr-MD237 is enhanced in flies heterozygous for Dl^EP3816.A.

The increase in bristle number at the site of the posterior notopleural macrochaete produced by expression of mam^H.Scer\UAS under the control of Scer\GAL4³⁰⁹ is enhanced in flies heterozygous for Dl^EP3816.A.

(Alexander et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Delta^unspecified

(Alexander et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Delta^EP3816.A

Dl^EP3816.A

EP 3816

(Alexander et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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