FlyBase Allele Report: Dmel\hpo[MGH4]

General Information

Symbol

Dmel\hpo^MGH4

Species

D. melanogaster

Name

FlyBase ID

FBal0193408

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Emoto et al., 2006)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Emoto et al., 2006)

Phenotype Manifest In

larval dorsal multidendritic neuron ddaC | somatic clone

(Emoto et al., 2006)

Detailed Description

Statement

Reference

Heterozygous larvae show no significant defects in dendrite morphology of ddaC neurons.

Heterozygous males do not have ectopic sex combs on the second or third legs.

(Parrish et al., 2007)

ddaC clones mutant for hpo^MGH4 exhibit simplified dendritic trees in third instar larvae, but show more extensive dendritic arborisations in earlier larval stages (second to early third instar), consistent with the involvement of hpo in the maintenance of dendrites. In hpo^MGH4 mutant clones at earlier developmental stages, dendritic branches are often found to overlap.

hpo^MGH4/+ heterozygotes exhibit wild-type dendritic tiling, with wild-type levels of dendritic crossing points per υm[2].

(Emoto et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

hpo^MGH4 has abnormal neuroanatomy phenotype, non-enhanceable by wts^x1/wts[+]

(Emoto et al., 2006)

Suppressed by

Statement

Reference

hpo^MGH4 has abnormal neuroanatomy phenotype, suppressible | partially by Scer\GAL4^elav-C155/trc^UAS.Tag:FLAG

(Emoto et al., 2006)

NOT suppressed by

Statement

Reference

hpo^MGH4 has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^elav-C155/wts^{UAS.L.Tag:MYC}

(Emoto et al., 2006)

Enhancer of

Statement

Reference

hpo^MGH4/hpo[+] is an enhancer of visible | dominant phenotype of Pc³

(Parrish et al., 2007)

Other

Statement

Reference

Pc³, hpo^MGH4/hpo[+] has abnormal neuroanatomy | dominant | somatic clone phenotype

(Parrish et al., 2007)

fry¹/fry[+], hpo^MGH4 has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

hpo^MGH4/hpo[+], trc² has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

fry¹, hpo^MGH4/hpo[+] has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

hpo^MGH4/hpo[+], trc¹ has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

hpo^MGH4, trc¹/trc[+] has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

hpo^MGH4, trc²/trc[+] has abnormal neuroanatomy phenotype

(Emoto et al., 2006)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

hpo^MGH4 has multidendritic dendrite phenotype, non-enhanceable by wts^x1/wts[+]

(Emoto et al., 2006)

Suppressed by

Statement

Reference

hpo^MGH4 has multidendritic dendrite phenotype, suppressible | partially by Scer\GAL4^elav-C155/trc^UAS.Tag:FLAG

(Emoto et al., 2006)

NOT suppressed by

Statement

Reference

hpo^MGH4 has multidendritic dendrite phenotype, non-suppressible by Scer\GAL4^elav-C155/wts^{UAS.L.Tag:MYC}

(Emoto et al., 2006)

Enhancer of

Statement

Reference

hpo^MGH4/hpo[+] is an enhancer of sex comb | ectopic phenotype of Pc³

(Parrish et al., 2007)

hpo^MGH4/hpo[+] is an enhancer of mesothoracic leg phenotype of Pc³

(Parrish et al., 2007)

hpo^MGH4/hpo[+] is an enhancer of metathoracic leg phenotype of Pc³

(Parrish et al., 2007)

Other

Statement

Reference

Pc³, hpo^MGH4/hpo[+] has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

fry¹/fry[+], hpo^MGH4 has multidendritic dendrite phenotype

(Emoto et al., 2006)

hpo^MGH4/hpo[+], trc² has multidendritic dendrite phenotype

(Emoto et al., 2006)

fry¹, hpo^MGH4/hpo[+] has multidendritic dendrite phenotype

(Emoto et al., 2006)

hpo^MGH4/hpo[+], trc¹ has multidendritic dendrite phenotype

(Emoto et al., 2006)

hpo^MGH4, trc¹/trc[+] has multidendritic dendrite phenotype

(Emoto et al., 2006)

hpo^MGH4, trc²/trc[+] has multidendritic dendrite phenotype

(Emoto et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Pc³/hpo^MGH4 double heterozygous larvae show dendritic defects in ddaC neurons; there is a significant reduction in the number of dendritic branchpoints.

The ectopic sex comb phenotype seen on the second and third legs of Pc³/+ males is enhanced by hpo^MGH4/+.

(Parrish et al., 2007)

hpo^MGH4 allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). hpo^MGH4 does not prevent loss of Df(1)su(s)R194/+ clones in the wing disc.

(Tyler et al., 2007)

Transheterozygotes for trc¹/hpo^MGH4 exhibit obvious iso-neuronal as well as hetero-neuronal tiling defects, including a significant increase in dendritic crossing-points compared to single mutants.

Transheterozygotes for trc²/hpo^MGH4 exhibit obvious iso-neuronal as well as hetero-neuronal tiling defects, including a significant increase in dendritic crossing-points compared to single mutants.

Transheterozygotes for fry¹/hpo^MGH4 exhibit obvious iso-neuronal as well as hetero-neuronal tiling defects, including a significant increase in dendritic crossing-points compared to single mutants.

Transheterozygotes for wts^x1/hpo^MGH4 display simplified dendrites similar to wts^x1 mutants.

Overexpression of trc^{Scer\UAS.T:Zzzz\FLAG}, under the control of Scer\GAL4^elav-C155 in hpo^MGH4 MARCM clones partially suppresses the dendritic tiling defects in class IV neurons.

Overexpression of wts^{Scer\UAS.L.T:Hsap\MYC}, under the control of Scer\GAL4^elav-C155 in hpo^MGH4 MARCM clones does not suppress the dendritic tiling defects in class IV neurons.

(Emoto et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hpo^MGH4 is rescued by Scer\GAL4^elav-C155/hpo^UAS.cEa

(Emoto et al., 2006)

hpo^MGH4 is rescued by hpo^UAS.cEa/Scer\GAL4^ppk.PG

(Emoto et al., 2006)

Comments

Both the dendritic tiling and maintenance phenotypes of hpo^MGH4 mutant clones are rescued by expression of hpo^Scer\UAS.cEa under the control of Scer\GAL4^elav-C155 or Scer\GAL4^ppk.PG (MARCM).

(Emoto et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hpo^MGH4

(Wang and Baker, 2015, Matsubara et al., 2011, Tyler et al., 2007)

hpo^mgh4

(Parrish et al., 2007, Emoto et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

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