In unc-5unspecified mutants, the dorsally projecting ISN inappropriately crosses the segment boundary and the SNa sometimes stalls or is missing one of the two major branches. However, ISNb guidance is normal.
unc-5unspecified is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4elav.PLu, fraΔC.UAS.Tag:HA, fraunspecified
unc-5unspecified is a non-suppressor of larval ventral nerve cord commissure | embryonic stage phenotype of Scer\GAL4elav.PLu, fraΔC.UAS.Tag:HA, fraunspecified
Expression of fraΔC.Scer\UAS.T:Ivir\HA driven by Scer\GAL4elav.PLu still causes a commissureless phenotype in a fraunspecified unc-5unspecified double mutant background.