FlyBase Allele Report: Dmel\fra[unspecified]

General Information

Symbol

Dmel\fra^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0151924

Feature type

allele

Associated gene

Dmel\fra

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

fra^unspecified mutants display EW axon guidance defects.

(Yang et al., 2009)

fra^unspecified embryos show SP1 axon midline crossing defects and SP1 cell body migration defects.

(Andrews et al., 2008)

The Fas2-positive longitudinal tracts are positioned farther apart from the midline than normal in mutant embryos.

(Bhat et al., 2007)

The nerve cord has missing or reduced commissural tracts in mutant 14 hour embryos and commissural defects are seen in every segment. The longitudinal connectives are farther away from the midline than normal; the medial tracts are positioned about 18μm apart in 14 hour mutant embryos, compared to about 9 μm apart in wild-type embryos. Earlier in development, at approximately 10 hours, the tracts from pCC neurons are projected farther away from the midline than normal.

(Bhat, 2005)

fra^unspecified mutants show trajectory defects of the ISN; this fascicle stalls, show excessive branching, crosses segment boundaries and projects beyond the dorsal target muscles. The ventral ISNb innervation of muscles 6 and 7 is disrupted but SNa innervations are normal.

(Labrador et al., 2005)

Mutant embryos show a range of defects in central nervous system axon guidance.

(Bashaw et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fra^unspecified has abnormal neuroanatomy phenotype, enhanceable by Dscam1⁰⁵⁵¹⁸/Dscam3^c02826

(Andrews et al., 2008)

fra^unspecified has abnormal neuroanatomy phenotype, enhanceable by RhoGEF64C^unspecified

(Bashaw et al., 2001)

Suppressed by

Statement

Reference

fra^unspecified has abnormal neuroanatomy | recessive | embryonic stage phenotype, suppressible by robo1¹

(Yang et al., 2009)

fra^unspecified has abnormal neuroanatomy | recessive | embryonic stage phenotype, suppressible by Scer\GAL4^eg-Mz360/comm^UAS.cKa

(Yang et al., 2009)

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by robo1¹

(Garbe et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by unc-5^unspecified

(Garbe et al., 2007)

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by sli²

(Garbe et al., 2007)

Suppressor of

Statement

Reference

fra^unspecified/fra[+] is a suppressor of abnormal neuroanatomy phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

fra^unspecified has SP1 neuron phenotype, enhanceable by Dscam1⁰⁵⁵¹⁸/Dscam3^c02826

(Andrews et al., 2008)

fra^unspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by RhoGEF64C^unspecified

(Bashaw et al., 2001)

Suppressed by

Statement

Reference

fra^unspecified has larval EW neuron phenotype, suppressible by Scer\GAL4^eg-Mz360/comm^UAS.cKa

(Yang et al., 2009)

fra^unspecified has larval EW neuron phenotype, suppressible by robo1¹

(Yang et al., 2009)

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has larval ventral nerve cord commissure | embryonic stage phenotype, suppressible | partially by robo1¹

(Garbe et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has larval ventral nerve cord commissure | embryonic stage phenotype, non-suppressible by unc-5^unspecified

(Garbe et al., 2007)

Scer\GAL4^elav.PLu, fra^{ΔC.UAS.Tag:HA}, fra^unspecified has larval ventral nerve cord commissure | embryonic stage phenotype, non-suppressible by sli²

(Garbe et al., 2007)

Enhancer of

Statement

Reference

fra^unspecified/fra[+] is an enhancer of symmetrical commissure | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

fra^unspecified/fra[+] is an enhancer of fascicle | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of comm^Scer\UAS.cKa under the control of Scer\GAL4^eg-Mz360 partially suppresses the EW axon guidance defects in fra^unspecified mutants.

The EW neuron guidance defects in fra^unspecified robo¹ double mutants are less severe than fra^unspecified single mutants.

(Yang et al., 2009)

The severity of the SP1 axon midline crossing defects seen in fra^unspecified embryos is enhanced in fra^unspecified Dscam⁰⁵⁵¹⁸ Dscam3^c02826 triple mutants.

(Andrews et al., 2008)

robo⁴, fra^unspecified double mutant embryos show a mixture of longitudinal tract phenotypes, ranging from a phenotype like that seen in the robo⁴ single mutant (collapsed tracts) to a phenotype like that seen in the fra^unspecified single mutant (tracts positioned further away from the midline than normal) and an intermediate phenotype, although the robo-like phenotype is predominant.

(Bhat et al., 2007)

When RhoGAP93B^{dsRNA.Scer\UAS} is driven by Scer\GAL4^elav.PLu in a fra^unspecified background no midline crossing defects are seen

(Hu, 2005)

Removal of a single copy of the fra gene leads to a threefold reduction in the number of midline crossovers induced by Gα49B^{Q203L.Scer\UAS} under the control of Scer\GAL4^elav-C155 (from 48.10% to 15.3% of abdominal segments exhibit midline crossing). A further reduction is observed upon removal of both copies of the fra gene in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴, from 48.10% of abdominal segments exhibiting midline crossover in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS} embryos to 5.3% in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴ mutant embryos.

(Ratnaparkhi et al., 2002)

Gef64C^unspecified enhances the axon guidance defects seen in fra^unspecified embryos; there is a substantial reduction in commissure thickness and a greater number of segments where commissures fail to form.

(Bashaw et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

fra^unspecified is not rescued by Scer\GAL4^eg-Mz360/fra^{ΔC.UAS.Tag:HA}

(Garbe et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fra(-)

(Garbe et al., 2007)

fra^unspecified

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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