FlyBase Allele Report: Dmel\Cp190[Ubi-p63E.PB]

General Information

Symbol

Dmel\Cp190^Ubi-p63E.PB

Species

D. melanogaster

Name

Ubiquitin-63E promoter construct of Butcher

FlyBase ID

FBal0190758

Feature type

allele

Associated gene

Dmel\Cp190

Associated Insertion(s)

Carried in Construct

P{Ubi-Cp190.D}

Key Links

Transgenic product class

cDNA

(Butcher et al., 2004)

wild_type

(Butcher et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Butcher et al., 2004)

wild_type

(Butcher et al., 2004)

Mutagen

in vitro construct

(Butcher et al., 2004)

Progenitor genotype

Carried in construct

P{Ubi-Cp190.D}

Cytology

Description

A Ubi-p63E promoter drives expression of full-length Cp190 cDNA.

(Butcher et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

Ubi-p63E

Encoded product / tool

Cp190

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

some die during P-stage | recessive

(Butcher et al., 2004)

some die during pupal stage | recessive

(Butcher et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Three out of seven transgenic Cp190^Ubi-p63E.PB lines are homozygous lethal at late-pupal stages of development, and the other four lines show an increase in the level of pupal mortality compared to wild type.

(Butcher et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cp190^Ubi-p63E.PB has lethal | recessive | partially | pupal stage phenotype, suppressible by Map60^Ubi-p63E.PB

(Butcher et al., 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Flies carrying two copies of the Cp190^Ubi-p63E.PB transgene, that normally show homozygous lethality, are viable as adults if they also carry a copy of the Map60^Ubi-p63E.PB transgene.

(Butcher et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Cp190^Ubi-p63E.PB rescues Cp190²

(Chodagam et al., 2005)

Cp190^Ubi-p63E.PB rescues Df(3R)P280-NR27/Cp190¹

(Butcher et al., 2004)

Cp190^Ubi-p63E.PB rescues Df(3R)P280-NR27/Cp190²

(Butcher et al., 2004)