FlyBase Allele Report: Dmel\Cp190[2]

General Information

Symbol

Dmel\Cp190²

Species

D. melanogaster

Name

FlyBase ID

FBal0190234

Feature type

allele

Associated gene

Dmel\Cp190

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Butcher et al., 2004)

Mutagen

ethyl methanesulfonate

(Butcher et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during P-stage (with Cp190¹)

(Butcher et al., 2004)

lethal - all die during P-stage (with Df(3R)P280-NR27)

(Butcher et al., 2004)

lethal - all die during P-stage | recessive

(Butcher et al., 2004)

some die during larval stage (with Cp190¹)

(Butcher et al., 2004)

some die during larval stage (with Df(3R)P280-NR27)

(Butcher et al., 2004)

some die during larval stage | recessive

(Butcher et al., 2004)

Phenotype Manifest In

cleavage nucleus

(Chodagam et al., 2005)

Detailed Description

Statement

Reference

Cp190² germ-line clone embryos have a severe axial-expansion defect; at nuclear cycle 7-8 the nuclei remain clustered toward the anterior of the embryo.

(Chodagam et al., 2005)

Cp190², Cp190²/Df(3R)P280-NR27 and Cp190¹/Cp190² mutants show some larval mortality, but approximately half the mutants survive until late pupal stages, dying as pharate adults. Cp190² larval brains show no obvious mitotic defects and the eyes, wings and cuticle of pharate adults appear normal, showing that tissue organization is not affected by a major defect in mitosis. Additionally, there are no observable meiotic defects in Cp190² larval testes.

(Butcher et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Cp190² has cleavage nucleus phenotype, suppressible by sqh^E20.E21

(Chodagam et al., 2005)

NOT suppressed by

Statement

Reference

Cp190² has cleavage nucleus phenotype, non-suppressible by sqh^{RLC.GFP(S65T)}

(Chodagam et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of one copy of the sqh^E20.E21 transgene partially restores axial expansion in Cp190² germ-line clone embryos. However, expression of one copy of the wild-type sqh^T:Avic\GFP transgene does not rescue this defect.

(Chodagam et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cp190² is rescued by Cp190^Ubi-p63E.PB

(Chodagam et al., 2005)

Df(3R)P280-NR27/Cp190² is rescued by Cp190^Ubi-p63E.PB

(Butcher et al., 2004)

Cp190² is rescued by Cp190^Ubi-p63E.PB

(Butcher et al., 2004)

Partially rescued by

Cp190² is partially rescued by Cp190^ΔM.Ubi-p63E

(Chodagam et al., 2005)

Cp190² is partially rescued by Cp190^ΔM.Ubi-p63E

(Butcher et al., 2004)

Comments

Expression of the Cp190^ΔM.Ubi-p63E transgene fails to rescue the axial-expansion defect of Cp190² flies.

(Chodagam et al., 2005)

The Cp190^ΔM.Ubi-p63E transgene rescues the lethality of Cp190² mutants so that ~80% of flies survive to adulthood. However, these adults are unhealthy and only survive for a few days.

(Butcher et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cp190²

(Fedotova et al., 2023, Melnikova et al., 2023, Sabirov et al., 2021, Erokhin et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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