FB2024_03 , released June 25, 2024
Allele: Dmel\eygΔPAI.ΔL.UAS
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General Information
Symbol
Dmel\eygΔPAI.ΔL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190527
Feature type
allele
Associated gene
Dmel\eyg
Associated Insertion(s)
Carried in Construct
P{UAS-eyg.ΔPAI.ΔL}
Key Links
Transgenic product class
dominant_negative_variant
(Yao and Sun, 2005)
inframe_deletion
(Yao and Sun, 2005)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Yao and Sun, 2005)
inframe_deletion
(Yao and Sun, 2005)
Mutagen
in vitro construct
(Yao and Sun, 2005)
Progenitor genotype
eyg554.UAS.Tag:NLS(SV40-largeT),Tag:FLAG
(Yao and Sun, 2005)
Carried in construct
P{UAS-eyg.ΔPAI.ΔL}
Cytology
Description

The PAI and L domains (amino acids 1-50) have been deleted.

(Yao and Sun, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
eyg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike overexpression of wild-type eyg, expression of eygΔPAI.ΔL.Scer\UAS, under the control of Scer\GAL4dpp.blk1, does not cause a ventral eye to form. Expression of eygΔPAI.ΔL.Scer\UAS in a eyg22-2/eygM3-12 background has a dominant-negative effect on the eye and thorax phenotype of these mutants.

      (Yao and Sun, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4eyg-22-2/eygΔPAI.ΔL.UAS fails to rescue eyg22-2/eygM3-12

      (Yao and Sun, 2005)
      Comments

      Expression of eygΔPAI.ΔL.Scer\UAS, under the control of Scer\GAL4eyg-22-2, causes a dominant-negative enhancement of the eye and thorax phenotypes of eyg22-2/eygM3-12 mutants.

      (Yao and Sun, 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eygΔPAI.ΔL.Scer\UAS
      eygΔPAI.ΔL.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)