FB2024_03 , released June 25, 2024
Allele: Dmel\PGRP-SC1aZ2-4761
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General Information
Symbol
Dmel\PGRP-SC1aZ2-4761
Species
D. melanogaster
Name
FlyBase ID
FBal0190196
Feature type
allele
Associated gene
Dmel\PGRP-SC1a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Garver et al., 2006)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PGRP-SC1aZ2-4761 mutant adults phagocytose E.coli and B.subtilis normally, but phagocytosis of dead S.aureus particles is reduced. Survival of these flies following E.coli infection is as wild-type, but lethality occurs much sooner following S.aureus infection than in wild-type and no accumulation of live S.aureus in phagosomes can be seen 24 hours after infection. :

      (Garver et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      PGRP-SC1aZ2-4761 is rescued by Scer\GAL4T155/PGRP-SC1aUAS.cGa

      (Garver et al., 2006)
      Partially rescued by

      PGRP-SC1aZ2-4761 is partially rescued by Scer\GAL4T155/PGRP-SC1am.UAS

      (Garver et al., 2006)
      Comments

      Phagocytosis of dead S.aureus particles in PGRP-SC1aZ2-4761 adults is rescued by PGRP-SC1aScer\UAS.cGa; Scer\GAL4T155 & partially rescued by PGRP-SC1am.Scer\UAS; Scer\GAL4T155. The rate of lethality in these flies due to infection with live S.aureus is slowed and the accumulation of live S.aureus into phagosomes is rescued by PGRP-SC1aScer\UAS.cGa; Scer\GAL4T155 and by PGRP-SC1am.Scer\UAS; Scer\GAL4T155 in the presence, but not the absence, of free S.aureus peptidoglycan. GA24. Gain of function data -- structured SoftCV

      (Garver et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Associated with: PGRP-SC1bZ2-4761

      (Garver et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PGRP-SC1aZ2-4761
      picky eaterZ2-4761
      (Garver et al., 2006)
      pickyZ4761
      (Garver et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)