FB2024_03 , released June 25, 2024
Allele: Dmel\eygmHD.UAS
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General Information
Symbol
Dmel\eygmHD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0189617
Feature type
allele
Associated gene
Dmel\eyg
Associated Insertion(s)
Carried in Construct
P{UAS-eyg.mHD}
Key Links
Transgenic product class
missense_variant
(Yao and Sun, 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yao and Sun, 2005)
Mutagen
in vitro construct
(Yao and Sun, 2005)
Progenitor genotype
eyg554.UAS.Tag:NLS(SV40-largeT),Tag:FLAG
(Yao and Sun, 2005)
Carried in construct
P{UAS-eyg.mHD}
Cytology
Description

The DNA binding residues of the HD domain have been disrupted (amino acid replacements S281A and N282A).

(Yao and Sun, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
eyg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Coexpression of the transgenes eygmHD.Scer\UAS and eygmPD.Scer\UAS, driven by Scer\GAL4dpp.blk1, results in the induction of an extra ventral in the ventral head region. Unlike overexpression of wild-type eyg, expression of eygmHD.Scer\UAS, under the control of Scer\GAL4dpp.blk1, does not cause extra ventral eye formation.

      (Yao and Sun, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      eygmHD.UAS/Scer\GAL4eyg-22-2 partially rescues eyg22-2/eygM3-12

      (Yao and Sun, 2005)
      Comments

      Expression of the eygmHD.Scer\UAS transgene in a eyg22-2/eygM3-12 background leads to the full rescue of eyes in 21% of mutants. The mutant thorax is fully rescued, although there are still many extra macrochaetes at lateral regions. Coexpression of the transgenes eygmHD.Scer\UAS and eygmPD.Scer\UAS in a eyg22-2/eygM3-12 background fully rescues the mutant eye and thorax phenotypes.

      (Yao and Sun, 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eygmHD.Scer\UAS
      eygmHD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)