FB2024_03 , released June 25, 2024
Allele: Dmel\wded06198
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General Information
Symbol
Dmel\wded06198
Species
D. melanogaster
Name
FlyBase ID
FBal0187491
Feature type
allele
Associated gene
Dmel\wde
Associated Insertion(s)
P{XP}wded06198
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
P{XP}wded06198
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{XP}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals homozygous for any of wded06198, wdeEY00884 or wdeTD63 mutant alleles or transheterozygous for any combination of the three alleles die at pupal stages. Rare escapers can be obtained by raising homozygous mutant larvae separated from their heterozygous siblings. Adult homozygous escapers are weak and survive only for a few days. The ovaries of homozygous mutant females are tiny and do not develop to the stage when egg chambers bud off from the germarium.

      Homozygous wded06198 mutant germ-line clones do not produce any eggs and do not develop beyond stage 8. The nuclei of germ-line cells are highly condensed and degenerate subsequently showing signs of apoptosis.

      (Koch et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      wded06198 is a non-enhancer of egg chamber | germline clone phenotype of egg1473

      (Koch et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      wded06198 is a non-suppressor of egg chamber | germline clone phenotype of egg1473

      (Koch et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The lethality and ovary phenotype of the wdeTD63 allele is fully rescued by wdeScer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL4da.G32.

      (Koch et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG12340d06198
      wde06198
      (Koch et al., 2009)
      wded06198
      Name Synonyms
      Secondary FlyBase IDs
        References (2)