FB2024_03 , released June 25, 2024
Allele: Dmel\Opa1f02779
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General Information
Symbol
Dmel\Opa1f02779
Species
D. melanogaster
Name
FlyBase ID
FBal0184800
Feature type
allele
Associated gene
Dmel\Opa1
Associated Insertion(s)
PBac{WH}Opa1f02779
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Yarosh et al., 2008)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Opa1f02779
Cytology
Description

Heterozygous mutant flies have lower levels of opa1-like protein than controls.

(Yarosh et al., 2008)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  optic atrophy
      CEA
      (Shahrestani et al., 2009, Yarosh et al., 2008)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Poole et al., 2008)
      modeled by park25, parkZ472
      (Poole et al., 2008)
      modeled by park25
      (Poole et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes do not show gross eye phenotypes.

      Small homozygous eye clones have a slightly rough appearance at low penetrance.

      Large homozygous eye clones (generated in a Minute background) exhibit a robust rough and glossy appearance, together with tissue necrosis of variable onset and penetrance.

      opa1-likef02779 mutant clones (in a Minute background) in pupal eye discs at 42h after pupal formation have a significantly reduced number of inter-ommatidial cells associated with a high degree of mis-patterning. These clones (at 42h APF) are not associated with increased reactive oxygen species production.

      At 42h after pupal formationopa1-likef02779 mutant clones (in a Minute background) in pupal eye discs exhibit pigmented cone cells with normal morphology and number. In adults, these clones have disorganized ommatidial structure: interommatidial cells are missing and cone cells are condensed with severe cell surface defects. The space between cone and interommatidial cells is also dramatically increased, consistent with cone/pigment cell death. These clones (in the adult) are associated with increased reactive oxygen species production.

      opa1-likef02779 mutant clones in adult eyes display normal rhabdomere structure, but scarce and dysmorphic mitochondria.

      (Yarosh et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Opa1[+]/Opa1f02779 is a suppressor | partially of abnormal flight phenotype of parkZ472/park25

      (Poole et al., 2008)

      Opa1[+]/Opa1f02779 is a suppressor | partially of visible phenotype of Pink1B9

      (Poole et al., 2008)

      Opa1[+]/Opa1f02779 is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Poole et al., 2008)

      Opa1[+]/Opa1f02779 is a suppressor of abnormal flight phenotype of park25

      (Poole et al., 2008)
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      Statement
      Reference

      Opa1[+]/Opa1f02779 is a suppressor | partially of adult thorax phenotype of parkZ472/park25

      (Poole et al., 2008)

      Opa1[+]/Opa1f02779 is a suppressor | partially of adult thorax phenotype of Pink1B9

      (Poole et al., 2008)

      Opa1[+]/Opa1f02779 is a suppressor of adult thorax phenotype of park25

      (Poole et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Opa1f02779/+ partially suppresses the thoracic indentation and impaired flight phenotypes of park25/park25 or park25/parkZ472 mutants.

      Opa1f02779/+ partially suppresses the thoracic indentation and impaired flight phenotypes of Pink1B9 hemizygous mutants.

      (Poole et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference

      Scer\GAL4ey.3.5.Exel-mediated expression of Hsap\SOD1Scer\UAS.cPa significantly reduces the glossy eye phenotype, but not the rough eye phenotype, of opa1-likef02779 large clones (induced in a Minute background).

      (Yarosh et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      CG8479f02779
      Opa1f02779
      dOpa1in3
      (Yarosh et al., 2008)
      opa1-likef02779
      opa1f02779
      (Poole et al., 2008)
      opa1f0
      (Poole et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)