FB2024_03 , released June 25, 2024
Allele: Dmel\parkZ472
Open Close
General Information
Symbol
Dmel\parkZ472
Species
D. melanogaster
Name
FlyBase ID
FBal0146933
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Whitworth et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: A46T.

    (Greene et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:21,196,525..21,196,525 [-]
    Nucleotide change:

    G21196525A

    Amino acid change:

    A60T | park-PB; A60T | park-PC

    Reported amino acid change:

    A46T

    Comment:

    The park protein reported in FBrf0159296 starts at an AUG that is 14 bases downstream of the annotated protein start accounting for the difference in the reported and annotated mutation location. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Greene et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Parkinson's disease
        CEA with park25
        (Poole et al., 2008)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        model of  Parkinson's disease
        is ameliorated by GstS1UASp.cWa
        (Whitworth et al., 2005)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The kinetics of the clearance of the paternal mitochondrial derivatives is normal in embryos derived from park25/parkZ472 males whose fertility has been rescued until a late spermatid stage by expression of parkT:Zzzz\TEV.CS followed by inactivation of the rescuing protein using cleavage by Zzzz\NIadj.PP.

        (Politi et al., 2014)

        Mitochondria form clusters in mutant follicles. Some of these mitochondria are doughnut shaped and some are larger than normal.

        (Cox and Spradling, 2009)

        park25/parkZ472 mutant adults display thoracic indentations and impaired flight ability.

        (Poole et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        parkZ472/park25 has abnormal flight phenotype, suppressible | partially by Opa1[+]/Opa1s3475

        (Poole et al., 2008)

        parkZ472/park25 has abnormal flight phenotype, suppressible | partially by Opa1[+]/Opa1f02779

        (Poole et al., 2008)

        parkZ472 has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4how-24B/GstS1UASp.cWa

        (Whitworth et al., 2005)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        parkZ472/park25 has adult thorax phenotype, suppressible | partially by Opa1[+]/Opa1s3475

        (Poole et al., 2008)

        parkZ472/park25 has adult thorax phenotype, suppressible | partially by Opa1[+]/Opa1f02779

        (Poole et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Opa1s3475/+ or Opa1f02779/+ partially suppresses the thoracic indentation and impaired flight phenotypes of park25/parkZ472 mutants.

        (Poole et al., 2008)

        Expression of GstS1Scer\UAS.P\T.cWa in the mesoderm, under the regulation of Scer\GAL4how-24B is sufficient to restore the climbing ability of parkZ472.

        (Whitworth et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        parkZ3-472
        (Politi et al., 2014)
        parkZ472
        (Cox and Spradling, 2009, Poole et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)