FB2024_03 , released June 25, 2024
Allele: Dmel\Dge01554
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General Information
Symbol
Dmel\Dge01554
Species
D. melanogaster
Name
FlyBase ID
FBal0184157
Feature type
allele
Associated gene
Dmel\Dg
Associated Insertion(s)
PBac{RB}Dge01554
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{RB}Dge01554
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Walker-Warburg syndrome
      modeled by rtP
      (Wairkar et al., 2008)
      exacerbates  congenital muscular dystrophy-dystroglycanopathy type A1
      modeled by rtP
      (Wairkar et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The mean amplitude of the evoked junctional current (EJC) is decreased by approximately 40% at the neuromuscular junction in homozygous larvae compared to controls. The miniature EJC amplitude is increased slightly in the mutant animals compared to controls. Quantal content is reduced by approximately 40% in the mutant larvae.

      (Bogdanik et al., 2008)

      Recordings from larval neuromuscular junctions (muscle 6 of A3 or 4) of Dge01554/Df(2R)ED2457 animals show a dramatic decrease in evoked synaptic transmission. However, the size and frequency of spontaneous mini excitatory junction potentials is normal. Short term facilitation is enhanced in these mutants.

      (Wairkar et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Evoked excitatory junction potentials are normal at the neuromuscular junctions of rtP/+ or Dge01554/+ larvae, but siginficantly reduced compared to wild-type in rtP/+; Dge01554/+ larvae. However, the size and frequency of spontaneous mini excitatory junction potentials is normal in transheterozygotes.

      (Wairkar et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dge01554
      dgP
      (Wairkar et al., 2008)
      dge01554
      (Bogdanik et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)