The mean amplitude of the evoked junctional current (EJC) is decreased by approximately 40% at the neuromuscular junction in homozygous larvae compared to controls. The miniature EJC amplitude is increased slightly in the mutant animals compared to controls. Quantal content is reduced by approximately 40% in the mutant larvae.
Recordings from larval neuromuscular junctions (muscle 6 of A3 or 4) of Dge01554/Df(2R)ED2457 animals show a dramatic decrease in evoked synaptic transmission. However, the size and frequency of spontaneous mini excitatory junction potentials is normal. Short term facilitation is enhanced in these mutants.
Dg[+]/Dge01554, rtP has abnormal neurophysiology phenotype
Dge01554, rt[+]/rtP has abnormal neurophysiology phenotype
Evoked excitatory junction potentials are normal at the neuromuscular junctions of rtP/+ or Dge01554/+ larvae, but siginficantly reduced compared to wild-type in rtP/+; Dge01554/+ larvae. However, the size and frequency of spontaneous mini excitatory junction potentials is normal in transheterozygotes.