FB2024_03 , released June 25, 2024
Allele: Dmel\Su(var)3-7P43
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General Information
Symbol
Dmel\Su(var)3-7P43
Species
D. melanogaster
Name
FlyBase ID
FBal0175785
Feature type
allele
Associated gene
Dmel\Su(var)3-7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bushey and Locke, 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: G416E. Nucleotide substitution: G1632A. (Coordinates relative to GenBank accession number X52187.1).

(Bushey and Locke, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,266,507..13,266,507 [+]
Nucleotide change:

G13266507A

Reported nucleotide change:

G1632A

Amino acid change:

G497E | Su(var)3-7-PA; G495E | Su(var)3-7-PB

Reported amino acid change:

G416E

Comment:

The annotated protein has an additional 81aa at the amino terminus relative to the reported (GB:X52187) protein accounting for the difference in the reported and curated mutation positions relative to the CDS.

(Bushey and Locke, 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When P{P-Sal}89D is present, the w gene of the P{lacW}ciDplac insertion variegates, resulting (in a w- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ciDplac is dominantly suppressed by Su(var)3-7P43.

      (Bushey and Locke, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(var)3-7P43
      (Haynes et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)