FlyBase Allele Report: Dmel\coro[ex6]

General Information

Symbol

Dmel\coro^ex6

Species

D. melanogaster

Name

FlyBase ID

FBal0175725

Feature type

allele

Associated gene

Dmel\coro

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Bharathi et al., 2004)

Mutagen

P-element activity

(Bharathi et al., 2004)

Progenitor genotype

coro⁴⁰⁹

(Bharathi et al., 2004)

Cytology

Description

Imprecise excision of the P{GAL4} element, resulting in translocation of 231bp from CG16791 into the third exon of coro. In addition there is also a 100bp deletion 1250bp upstream of the transcription site.

(Bharathi et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | recessive

(Bharathi et al., 2004)

some die during pupal stage | recessive

(Bharathi et al., 2004)

Phenotype Manifest In

anterior-posterior compartment boundary of the wing disc (with coro^ex11)

(Bharathi et al., 2004)

dorsal mesothoracic disc & cytoskeleton

(Bharathi et al., 2004)

dorsal-ventral compartment boundary of the wing disc (with coro^ex11)

(Bharathi et al., 2004)

leg (with coro^ex11)

(Bharathi et al., 2004)

wing disc

(Bharathi et al., 2004)

wing disc (with coro^ex11)

(Bharathi et al., 2004)

Detailed Description

Statement

Reference

The wing imaginal disc actin-cytoskeleton is severely disrupted in coro^ex6. Wing discs are very small and often show reduction of the wing pouch area. coro^ex6/coro^ex11 pharate adults often show total loss of one or more legs. A small number of coro^ex6/coro^ex11 wing discs show a deep cleft along either the AP or DV boundary. Wing discs are very small and often show reduction of the wing pouch area.

(Bharathi et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

coro^ex6 has lethal | larval stage phenotype, enhanceable by Scer\GAL4^dpp.blk1/Syx1A^DN.UAS

(Bharathi et al., 2004)

Enhancer of

Statement

Reference

coro^ex6, Scer\GAL4^dpp.blk1, coro[+] is an enhancer of visible phenotype of tkv^{Q253D.UAS.cNb}

(Bharathi et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

coro^ex6/coro^ex11 has dorsal mesothoracic disc & cytoskeleton phenotype, suppressible by dpp^UAS.T.EGFP/Scer\GAL4^dpp.blk1

(Bharathi et al., 2004)

coro^ex6 has dorsal mesothoracic disc & cytoskeleton phenotype, suppressible by dpp^UAS.T.EGFP/Scer\GAL4^dpp.blk1

(Bharathi et al., 2004)

Enhancer of

Statement

Reference

coro^ex6, Scer\GAL4^dpp.blk1, coro[+] is an enhancer of anterior-posterior compartment boundary of the wing disc phenotype of tkv^{Q253D.UAS.cNb}

(Bharathi et al., 2004)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, coro^ex6, dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex6, tkv^{Q253D.UAS.cNb} has anterior-posterior compartment boundary of the wing blade phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex6/coro^ex11, dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex6/coro[+], dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Discs overexpressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1 in coro^ex6 homozygous or heterozygous mutants or coro^ex6/coro^ex11 transheterozygous mutants are much larger than wild-type discs expressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1. In coro^ex6 homozygous mutants and coro^ex6/coro^ex11 mutants, a partial rescue of the actin cytoskeleton and apicobasal polarity is seen in wing discs overexpressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1. Overexpression of tkv^{Q253D.Scer\UAS.cNb} under the control of Scer\GAL4^dpp.blk1 in coro^ex6 heterozygous backgrounds causes a severe cleft phenotype with 85% penetrance along the AP boundary of the wing disc. Enhancement is more pronounced in adult wing blades. Overexpression of Syx1A^DN.Scer\UAS driven by Scer\GAL4^dpp.blk1 enhances lethality in the coro^ex6 homozygous background; the double mutants die at the early third larval stage.

(Bharathi et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38103

w¹¹¹⁸; coro^ex6/CyO; l(3)*^*, e^*/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

coro^ex6

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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