FB2024_03 , released June 25, 2024
Allele: Dmel\hdmg7
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General Information
Symbol
Dmel\hdmg7
Species
D. melanogaster
Name
FlyBase ID
FBal0175652
Feature type
allele
Associated gene
Dmel\hdm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Two pro-oocytes are visible in 62.5% of region 3 cysts in homozygous females (as assayed by c(3)G staining) compared to a frequency of 9.5% in wild type.

        (Joyce and McKim, 2009)

        In hdmg7 mutants, crossing over is reduced to approximately 30% of wild-type. The distribution of the residual crossovers is nonrandom.

        (Joyce and McKim, 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        hdmg7 has stage S1 oocyte | increased number phenotype, suppressible by Sirt117/Df(2L)BSC245

        (Joyce and McKim, 2010)

        hdmg7 has presumptive oocyte phenotype, suppressible by mei-2181

        (Joyce and McKim, 2009)

        hdmg7 has presumptive oocyte phenotype, suppressible by rec2/rec1

        (Joyce and McKim, 2009)

        hdmg7 has presumptive oocyte phenotype, suppressible by pch2EY01788a

        (Joyce and McKim, 2009)
        NOT suppressed by
        Statement
        Reference

        hdmg7 has presumptive oocyte phenotype, non-suppressible by mei-W684572

        (Joyce and McKim, 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The high frequency of region 3 cysts containing two pro-oocytes that is seen in hdmg7 homozygous females is suppressed by pch2EY01788a, mei-2181 or rec1/rec2, but is not suppressed by mei-W684572.

        pch2EY01788a enhances the increased X chromosome non-disjunction phenotype seen in hdmg7 females.

        (Joyce and McKim, 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG15329g7
        g7
        (Joyce, 2005.3.3, Joyce and McKim, 2005)
        hdmg7
        (Joyce and McKim, 2010, Joyce and McKim, 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)