FB2024_03 , released June 25, 2024
Allele: Dmel\rec1
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General Information
Symbol
Dmel\rec1
Species
D. melanogaster
Name
FlyBase ID
FBal0014514
Feature type
allele
Associated gene
Dmel\rec
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Nucleotide substitution: C889T.

(Blanton et al., 2005)

Amino acid replacement: Q297term.

(Blanton et al., 2005)

Amino acid replacement: Q?term.

(Matsubayashi and Yamamoto, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,831,729..15,831,729 [-]
Nucleotide change:

C15831729T

Reported nucleotide change:

C889T

Reported nucleotide change:

C904T

Amino acid change:

Q297term | rec-PA; Q297term | rec-PB

Reported amino acid change:

Q297term

Reported amino acid change:

Q?term

(Blanton et al., 2005, Matsubayashi and Yamamoto, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The frequency of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining) in rec1/rec2 females is not significantly different from that seen in wild-type females.

      (Joyce and McKim, 2009)

      rec1/rec2 mutant females show reduction in the overall frequency of crossing over on the second chromosome compared to wild type. The reduction in crossing over in the centromere-proximal interval is more modest than the total reduction in crossing over frequency.

      (Blanton et al., 2005)

      Homozygous females show a high frequency of primary nondisjunction of the X chromosome. Meiotic recombination on the X chromosome is significantly reduced in homozygous females.

      (Matsubayashi and Yamamoto, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rec2/rec1 is a suppressor of presumptive oocyte phenotype of hdmg7

      (Joyce and McKim, 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The high frequency of region 3 cysts containing two pro-oocytes that is seen in hdmg7 homozygous females is suppressed by rec1/rec2.

      (Joyce and McKim, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      rec1 is rescued by recHsp83.PM

      (Matsubayashi and Yamamoto, 2003)
      Comments

      recHsp83.PM rescues the the X chromosome nondisjunction and recombination defects which are seen in homozygous rec1 females.

      (Matsubayashi and Yamamoto, 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      R.F. Grell & E.E. Generoso, Nov. 1972.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (8)