FlyBase Allele Report: Dmel\mei-W68[4572]

General Information

Symbol

Dmel\mei-W68⁴⁵⁷²

Species

D. melanogaster

Name

FlyBase ID

FBal0141038

Feature type

allele

Associated gene

Dmel\mei-W68

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Lake et al., 2011, Liu et al., 2002)

abnormal meiotic cell cycle | female

(Lake et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

mei-W68⁴⁵⁷² females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

(Lake et al., 2019)

The number of meiotically-induced double stranded breaks in homozygous mei-W68⁴⁵⁷² mutant females is reduced compared to wild type.

(Lake et al., 2011)

Homozygous females show a low frequency (24.0%) of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining).

(Joyce and McKim, 2009)

Meiotic recombination is eliminated in mutants.

(Liu et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

c(2)M^EP2115, mei-W68⁴⁵⁷² has abnormal meiotic cell cycle phenotype

(Manheim and McKim, 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

mei-W68⁴⁵⁷² is a suppressor of karyosome | heat sensitive phenotype of tefu^atm-8

(Joyce et al., 2011)

NOT Suppressor of

Statement

Reference

mei-W68⁴⁵⁷² is a non-suppressor of presumptive oocyte phenotype of hdm^g7

(Joyce and McKim, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The karyosome morphology defects found in female tefu^atm-8 mutants at the restrictive temperature of 25[o]C are suppressed in a mei-W68⁴⁵⁷² mutant background.

All γ-His2Av staining is eliminated in mei-W68⁴⁵⁷²; tefu^atm-8 double mutants, indicating that the abundant γ-His2Av staining in the tefu^atm-8 mutant is dependent on the induction of meiotic double strand breaks.

(Joyce et al., 2011)

The high frequency of region 3 cysts containing two pro-oocytes that is seen in hdm^g7 homozygous females is not suppressed by mei-W68⁴⁵⁷².

(Joyce and McKim, 2009)

c(2)M^EP2115, mei-W68⁴⁵⁷² double mutant mothers show a decrease in crossovers in most chromosomal regions, though not in the st-cu region.

(Manheim and McKim, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mei-W68⁴⁵⁷²

(Lake et al., 2019, Lake et al., 2015, Joyce et al., 2011, Lake et al., 2011, Joyce and McKim, 2010, Joyce and McKim, 2009, Jang et al., 2003)

mei-W68^z4572

(Lake et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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