FB2024_03 , released June 25, 2024
Allele: Dmel\jusf04904
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General Information
Symbol
Dmel\jusf04904
Species
D. melanogaster
Name
FlyBase ID
FBal0162251
Feature type
allele
Associated gene
Dmel\jus
Associated Insertion(s)
PBac{WH}jusf04904
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{WH}jusf04904
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  epilepsy
      CEA
      (Dean et al., 2018, Horne et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      jusf04904 homozygotes, jusiso7.8/jusf04904 transheterozygotes and jusf04904/Df(3R)BSC501 transheterozygotes show an abnormal and fully penetrant paralysis phenotype upon exposure to 14[o]C or 10[o]C temperatures, which is associated with a significant increase in recovery time from paralysis upon shift to room temperature, as compared to wild-type controls; jusf04904 heterozygotes also show an abnormal and highly penetrant paralysis phenotype upon exposure to 10[o]C, but not 14[o]C, temperatures, despite of an apparently normal recovery time from paralysis upon shift to room temperature, as compared to wild-type controls.

      (Dean et al., 2018)

      jusf04904 as well as jusiso7.8/jusf04904 and jusf04904/Df(3R)BSC501 flies are bang sensitive with jusiso7.8/jusf04904 displaying the shortest and jusf04904/Df(3R)BSC501 the longest recovery time.

      High frequency electrical stimulation of jusf04904 mutant flies induces primary seizure occuring immediately after the stimulus followed by a secondary 'recovery' seizure around 70 sec later - this is significantly longer than in the jusiso7.8 mutants where the average interval between seizures is only about 30 sec, the seizure stimulus threshold however is comparable between the mutants.

      (Horne et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      jusiso7.8

      (Horne et al., 2017)
      Partially rescued by

      jusf04904/jusiso7.8 is partially rescued by jusTag:TY1,sfGFP,Tag:V5,Tag:BLRP,Tag:FLAG

      (Horne et al., 2017)
      Comments

      The bang-sensitivity phenotype of jusiso7.8 mutants cannot be complemented by combination with jusf04904.

      The median recovery time after mechanical shock-induced paralysis of jusiso7.8/jusf04904 flies is significantly shortened by combination with a single copy of jusT:Scer\TY1,T:Avic\GFP-SF,T:SV5\V5,T:Zzzz\BLRP,T:Zzzz\FLAG.

      (Horne et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG14509f04904
      (Horne et al., 2017)
      jusf04904
      (Dean et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)